声触诊组织定量技术在鉴别诊断甲状腺结节良恶性中应用.pdfVIP

Application of virtual touch tissue quantification techniques in the differential diagnosis between benign and malignant thyroid nodules Abstract 0bjective To mvestigate the clinical value of virtual touch tissue quantification(VTQ)technique ofacoustic radiation force impulse imaging(ARFI)in differentiating malignant thyroid nodules from benign ones，and fl／／ther to explore the impact factors ofVTQ elastography in the evaluation ofthyroid nodules． Methods 1 80 thyroid nodules in 1 65 patients were analyzed by 2D ultrasound，color Doppler flow irnaging(CDFI)and VTQ elastography．VTQ was used to determine the stiffiaess of the nodules and adjacent tissues of thyroid by measuring the value of shear wave velocities(swv)at cross and longitudinal sections scanning，and then calculated difference between the nodules and the surrounding thyroid tissues．Receiver operating characteristic(ROC)curve was used to evaluate the diagnostic performance ofVTQ and to find the best cut-off point．Z test was used to compare the diagnostic performance of these three methods in diagnosis of thyroid nodules．The multiple linear regression was used to analyze the relationship between the S、vV of nodules and nodules maximunl size． internal calcification，intranodular blood flow，nodules depth to the skin,probe scanning direction as well as pathologic finding． Results①1 80 nodules included 65 benign nodules(54 nodular goiters and 11 adenomas)and l 1 5 malignant nodules(1 1 4 papillary carcinomas and 1 follicular carcinoma)．At cross and longitudinal sections．the mean SWV in benign nodules and the adjacent thyroid tissues were(2．15+0．78)rn／s，(1．93：￡0．47)m／s and(2．22_-￡0．71)m／s， (2．06士O．4 1)rn／s，respectively,while in malignant thyroid nodules and the adjacent thyroid tissues were(2．97士1．12)rn／s，(1．90-士0．48)m／s and(3．09士1．08)rn／s，(1．97+0．44)m／s， respectively．②A significant difference in mean SWV WaS found between malignant thyroid nodules on one hand and benign thyroid nodules妒0．0001)or the adjacent thyro