叶酸对老年H型高血压患者同型半胱氨酸及颈动脉内膜厚度的影响.docVIP

叶酸对老年H型高血压患者同型半胱氨酸及颈动脉内膜厚度的影响 　　摘 要 目的：观察叶酸治疗老年H型高血压患者时是否降低同型半胱氨酸（homocysteine， Hcy）水平，从而减少因Hcy增高引起的心脑血管意外事件。方法：收集2013年11月至2015年2月H型高血压老年（65～75岁）患者100例，分为治疗组和对照组各50例。两组均采用正规抗高血压药物治疗，治疗组同时口服0.8 mg叶酸。两组患者每6个月检测Hcy水平，观察12个月，并在12个月后观察颈动脉内膜变化。结果：治疗6和12个月时，治疗组Hcy水平为15.08 μmmol/L，12个月后为12.97 μmmol/L，较治疗前明显下降；对照组分别为16.01 μmmol/L和17.00 μmmol/L，与治疗前变化不明显。治疗组颈动脉内膜厚度改变较对照组明显（P0.05）。结论：口服叶酸可有效降低Hcy水平，减少颈动脉内膜厚度，从而减少H型高血压患者的并发症。 　　关键词 高血压 同型半胱氨酸 叶酸 老年人 　　中图分类号：R544.1/R 文献标识码：A 文章编号：1006-1533（2016）06-0021-03 　　Influence of folic acid on the homocysteine and carotid intima thickness of the elderly H hypertension patients 　　MAO Weijuan， KONG Chunhui， ZHOU Ying 　　（Laoximen Community Health Service Center of Huangpu District， Shanghai 200010， China） 　　ABSTRACT Objective： To observe whether folic acid can reduce homocysteine（ HCY） levels when it was used to treat the elderly H hypertension patients so as to reduce the cardiovascular accident events caused by the increased HCY. Methods： From Nov. 2013 to Feb. 2015， 100 cases of elderly H hypertension patients （65～75 years old） were collected and divided into a treatment group and a control one with 50 cases each. Both groups were treated with the regular anti hypertensive drug， and the treatment group were additionally given the oral administration of 0.8 mg folic acid at the same time. HCY levels were detected in the two groups every 6 months and observed for 12 months. The changes in carotid intima were observed after 12 months. Results： HCY levels were 15.078 μmmol/L and 12.974 μmmol/L in the treatment group in the 6th month and 12th month， which were greatly reduced compared with those before treatment and HCY levels were 16.010 μmmol/L and 16.998 μmmol/L in the control group， which showed little change. The change of the carotid artery intima thickness was more significant in the treatment group than in the control group （P0.05）. Conclusion： Oral administration of folic acid can effectively reduce HCY levels and carotid i