Effectof3weeksofLY333531(LY)(1mgkgday)orL-NIL(3.pptVIP

Effect of 3 weeks of LY333531 LY 1 mg/kg/day or L-NIL 3 mg/kg/day treatment on hemodynamic parameters in freely moving conscious rats. Prabhakara Reddy Nagareddy et al. Diabetes 2009;58:2355-2364 ?2009 by American Diabetes Association Effect of 3 weeks of LY333531 LY 1 mg/kg/day or L-NIL 3 mg/kg/day treatment on hemodynamic parameters in freely moving conscious rats. Data represent means ± SE n 8 . A: Effect of LY333531 or L-NIL on MABP. *P 0.05 compared with all other groups. B: Effect of LY333531 or L-NIL on heart rate. *P 0.05 compared with all other groups. C: Effect of LY333531 or L-NIL on endothelial function as measured by the change in blood pressure ΔMABP in response to a single intravenous bolus dose of l-NAME 10 mg/kg in control C and diabetic D rats. *P 0.05 compared with their respective control groups. #P 0.05 compared with diabetic and diabetic + LY333531 groups. D: Effect of LY333531 or L-NIL on pressor responses to bolus doses of methoxamine 100–300 nmoles/kg . *P 0.05 compared with all other groups; #P 0.05 compared with diabetic rats.