盐酸羟考酮对妇科腹腔镜术后苏醒期患者的镇痛效果.docVIP

盐酸羟考酮对妇科腹腔镜术后苏醒期患者的镇痛效果 　　[摘要] 目的 探讨盐酸羟考酮在妇科腹腔镜苏醒期的镇痛效果。 方法 选择2012年1月～2015年12月廊坊市人民医院收治的112例全麻下行妇科腹腔镜手术的患者，2012年1月～2013年12月收治66例患者为对照组，2014年1月～2015年12月收治46例患者为治疗组。两组均采取舒芬太尼、丙泊酚、顺阿曲库铵诱导麻醉，阿曲库铵、瑞芬太尼维持麻醉。瑞芬太尼停用前10 min治疗组静脉注射1 mg/mL盐酸羟考酮0.08 mg/kg，对照组给予同剂量吗啡。比较两组苏醒期状态、血流动力学、VRS值。 结果 治疗组的心率、收缩压在术毕、拔管5 min时与基础值比较变化幅度较对照组小，差异有统计学意义（P 0.05）。治疗组在拔管即刻的静息、运动VAS值均显著低于对照组，差异有高度统计学意义（P 0.01）。 结论 盐酸羟考酮注射剂具有较好的内脏镇痛效果，且对血流动力学的稳定性控制较好。 　　[关键词] 妇科腹腔镜；苏醒期；盐酸羟考酮 　　[中图分类号] R614 [文献标识码] A [文章编号] 1673-7210（2016）05（a）-0048-05 　　[Abstract] Objective To explore the effect of oxycodone hydrochloride in patients at recovery period after gynecologic laparoscopic operation. Methods From January 2012 to December 2015， in Peoples Hospital of Langfang City， 112 patients undergoing gynecologic laparoscopic operation were selected， the 66 patients from January 2012 to December 2013 were as control group， 46 patients from January 2014 to December 2015 were as treatment group. The two groups were given Sufentanil， Propofol and Cisatracurium induced anesthesia， and Propofol， Remifentanil maintained anesthesia. Before stoping Remifentanil 10 minutes， the treatment group was given 1 mg/mL intravenous oxycodone hydrochloride 0.08 mg/kg， the control group was given the same dose of morphine. The recovery period state， hemodynamics and the VAS of the two groups were compared. Results The change of heart rate， systolic blood pressure at the end of operation and tube drawing 5 min compared with the basic value in the treatment group were significantly lower than those in the control group， the differences were statistically significant （P 0.05）. The VAS in resting and exercise at tube drawing in the treatment group were significantly lower than those in the control group， the differences were statistically significant （P 0.01）. Conclusion Oxycodone hydrochloride injection has better visceral analgesic effect and control of hemodynamic stability. 　　[Key words] Gynecologic laparoscopic operation； Rec