睡眠呼吸暂停综合征的肾脏损害.docVIP

睡眠呼吸暂停综合征的肾脏损害 　　[摘要] 目的 对睡眠呼吸暂停综合征的肾脏损害进行探讨。 方法 整群选取2014年9月―2015年9月期间该院收治的睡眠呼吸暂停综合征患者作为研究组，共计59例，另择取同期来该院体检的健康人作为对照组，共计50例 。比较两组受检者的尿蛋白/肌酐、Cys-C、GFR等各项指标检测结果，并观察不同程度睡眠呼吸暂停综合征患者各项指标之间的差异。 结果 轻度睡眠呼吸暂停综合征患者的ACR、Cys-C、GFR水平分别为（8.0±0.9）、（0.86±0.12）、（104.1±14.5）mL/（min?1.73m2），与健康对照组（ACR、Cys-C、GFR水平分别为（8.0±1.1）、（0.85±0.12）、（115.6±19.3）mL/（min?1.73m2））差异无统计学意义（P0.05），但均优于中度睡眠呼吸暂停综合征患者（ACR、Cys-C、GFR水平分别为（11.8±1.2）、（0.98±0.16）、（94.9±12.2）mL/（min?1.73m2）），优于重度睡眠呼吸暂停综合征患者（ACR、Cys-C、GFR水平分别为（26.9±3.1）、（1.34±0.27）、（90.8±13.5）mL/（min?1.73m2）），比较差异有统计学意义（P0.05）。 结论 睡眠呼吸暂停的患者对肾脏病影响严重，临床上应针对睡眠呼吸暂停综合征的患者，采取适宜方式治疗并改善患者症状。 　　[Abstract] Objective To discuss the kidney damage of sleep apnea syndrome. Methods 59 cases of patients with sleep apnea syndrome treated in our hospital from September 2014 to September 2015 were selected as the research group and 50 cases of healthy people with physical examination in our hospital at the same period were selected as the control group， the test results of each indicator including urine protein/creatinine ratio， Cys-C and GFR were compared， the differences between each indicator in patients with sleep apnea syndrome of different degrees were observed. Results The ACR， Cys-C and GFR levels were respectively （8.0±0.9），（0.86±0.12）and （104.1±14.5）mL/（min?1.73m2） in patients with mild sleep apnea syndrome and（8.0±1.1）， （0.85±0.12）and（115.6±19.3）mL/（min?1.73m2）in healthy people， and the differences were not obvious（P0.05），which were better than those in patients with moderate sleep apnea syndrome （11.8±1.2），（0.98±0.16）， （94.9±12.2）mL/（min?1.73m2） and patients with severe sleep apnea syndrome（26.9±3.1），（1.34±0.27），（90.8±13.5）mL/（min?1.73m2）， all comparisons had statistical differences，（P0.05）. Conclusion The effect of sleep apnea syndrome on kidney diseases is serious， and we should take the appropriate methods to treat the patients with？sleep apnea syndrome in clinic and improve the patient’s symptoms. 　　[Key words] Sleep apnea syndrome； Kidney d