臭氧联合胶原酶对腰椎间盘突出症的临床应用.docVIP

臭氧联合胶原酶对腰椎间盘突出症的临床应用 　　[摘要] 目的 探究和分析臭氧联合胶原酶注射治疗腰椎间盘突出症疗效及价值。 方法 研究对象为随机选取2013年1月―2015年1月期间该院收治的腰椎间盘突出症患者40例，随按照随机数字表法分为研究组、对照组各20例。对照组采用开窗腰椎间盘摘除术，研究组采用臭氧联合胶原酶注射治疗，对比两组治疗前后生化指标水平变化及并发症发生情况。 结果 经臭氧联合胶原酶注射治疗后，研究组患者TXB2（35.43±7.24），IL-IP（0.14±0.05），TNFα（0.88±0.22），与治疗前相比均显著好转，且优于对照组，差异有统计学意义（P0.05）。 结论 臭氧联合胶原酶注射疗法治疗腰椎间盘突出症效果显著，且并发症少，治疗安全，患者依从性好，是腰椎间盘突出症的有效治疗手段。 　　[Abstract] Objective To discuss and analyze the curative effect and value of ozone combined with collagenase for lumbar disc herniation. Methods 40 cases of patients with lumbar disc herniation treated in our hospital from January 2013 to January 2015 were selected as the research object and divided into two groups with 20 cases in each， the control group were treated with open lumbar discectomy， the research group were treated with ozone combined with collagenase， the change of biochemical index level and occurrence of complications before and after treatment of the two groups were compared. Results The TXB2， IL-IP and TNFα in the research group after the treatment of ozone combined with collagenase were respectively （35.43±7.24），（0.14±0.05）and（0.88±0.22）， which were obviously improved compared with those before treatment and were better than those in the control group， the differences were statistically significant（P0.05）. Conclusion The injection therapy of ozone combined with collagenase in treatment of lumbar disc herniation has an obvious curative effect， few complications， safe treatment and good compliance， which is an effective treatment means of lumbar disc herniation. 　　[Key words] Lumbar disc herniation； Ozone； Collagenase 　　腰椎间盘突出症是骨外科较为常见的症状，临床主要症状为腰部下段的疼痛和肢体下部放射样疼痛，对患者的生活及工作均产生了较大的影响。对于该病的发病机制和临床治疗，人类已有近上千年的认识。近十几年，由欧洲国家推荐的臭氧腰椎间盘内注射治疗技术被引入国内，并逐渐在临床开展。有研究证明，由于臭氧具有较强的氧化性，当椎间盘中注入臭氧后可能会导致蛋白多糖的作用减弱甚至消失，髓核组织水分流失从而使其出现坏死、变性、萎缩等，纤维环回缩后可改善神经根的压迫程度，此外，臭氧还具有局部的免疫机制，降低神经根的炎症及水肿程度，使腰椎间盘突出症的到缓解及改善[1]。现随机选取2013年1月―2015年1月期间在该院进行治疗的腰椎间盘突出症患者40例进行研究，旨在探究在腰椎间盘突出症的治疗中以臭氧结合胶原酶注射治疗的临床效果，现报道如下。 　　1 资料与方法 　　1