Pharmacokinetics08.pptVIP

Drugs need to achieve an adequate concentration in their target tissues. The two fundamental processes that determine the concentration of a drug at any moment and in any region of the body are: translocation of drug molecules chemical transformation by drug metabolism and other processes involved in drug elimination These are critically important for choosing appropriate routes of administration The Movement of Drug Molecules Across Cell Barriers, Lipid solubility: weak acids and weak bases/Clinical Significance The Movement of Drug Molecules Across Cell Barriers, Lipid solubility: weak acid