D―二聚体水平变化与类风湿关节炎病情活动性的相关性分析.docVIP

D―二聚体水平变化与类风湿关节炎病情活动性的相关性分析 　　[摘要] 目的 探讨类风湿关节炎（RA）患者中血浆D-二聚体（D-D）水平变化，并分析其与各临床指标的关系。 方法检测138例RA患者和47例正常对照组患者血浆D-二聚体水平，分析其与年龄、类风湿因子（RF）、红细胞沉降率（ESR）、视觉模拟评分（VAS评分）、血小板的相关性。 结果 RA组血浆D-二聚体水平明显高于健康对照组，差异有统计学意义（P0.01）；病情高活动组、病情低活动组RA患者D-二聚体水平明显高于病情缓解组RA患者（P均0.01）；病情高活动组RA患者D-二聚体水平明显高于病情低活动组（P0.01）；所有RA患者D-二聚体水平与年龄、ESR、VAS评分、RF、血小板均呈明显正相关（P均0.01）。 结论 RA患者体内存在高凝状态，D-二聚体可作为临床判断RA患者病情活动的非特异性炎性反应指标，亦可指导临床治疗。 　　[关键词] 类风湿关节炎；D-二聚体；VAS评分；红细胞沉降率；类风湿因子 　　[中图分类号] R593.22 [文献标识码] B [文章编号] 1673-9701（2015）12-0048-03 　　Correlation analysis between D-dimer level changes and rheumatoid arthritis （RA） disease activity 　　ZHANG Zhuqing1 ZHU Yun2 ZHANG Bin2 MA Jingjing2 CHANG Luyan1 　　1.Department of Internal Medicine，Weifang Medical University，Weifang 261041， China； 2.Department of Rheumatology and Immunology， Weifang People’s Hospital Affiliated to Weifang Medical University， Weifang 261053， China 　　[Abstract] Objective To study the plasma D-dimer （DD） level changes in the patients with rheumatoid arthritis （RA）， and to analyze its correlation with various clinical indicators. Methods Selected a total of 138 cases of RA patients and 50 cases of normal person as matched group the plasma D-dimer level and the correlation analysis with age， rheumatoid factor （RF）， erythrocyte sedimentation rate （ESR）， visual analogue scale （VAS score）and platelet were analyzed. Results The level of D-dimer level in RA patients was significantly higher than that of healthy controls， and the difference was statistically significant （P0.01）； The D-dimer level of high disease activity group and low disease activity group with RA patients were significantly higher than the remission groups of RA patients （P all 0.01）； The D-dimer level in high disease activity group of RA patients was significantly higher than the low disease activity group （P0.01）； There were positive correlations between the D-dimer level and the age， ESR， VAS score， RF， platelet in all RA patients（P all 0.01）. Conclusion There is high