论炔雌醇环丙孕酮治疗多囊卵巢综合症疗效分析.docVIP

论炔雌醇环丙孕酮治疗多囊卵巢综合症疗效分析 　　[摘要] 目的 探讨炔雌醇环丙孕酮治疗多囊卵巢综合症的临床效果。 方法 对该院2011年6月―2014年6月收治的采取炔雌醇环丙孕酮治疗的112例PCOS患者进行分析，观察治疗前后经量、经期变化及LH、FSH、E2、T、PRL情况，观察治疗后卵巢及卵泡变化。 结果 治疗后经量恢复107例，周期30.6±4.3d，较治疗前差异有统计学意义（P0.05）；治疗后LH、FSH、E2、T、PRL水平较治疗前均有下降，以LH、FSH、T水平下降显著，E2及PRL水平无明显改变；治疗后卵巢体积及卵泡数较治疗前明显变小、变少。 结论 炔雌醇环丙孕酮片可有效改善PCOS患者临床症状和内分泌情况，对恢复月经周期和排卵有重要作用，是治疗PCOS的有效药物，值得临床使用。 　　[关键词] 炔雌醇环丙孕酮；多囊卵巢综合症 　　[中图分类号] R711.75 [文献标识码] A [文章编号] 1674-0742（2015）02（c）-0113-02 　　[Abstract] Objective To investigate the clinical effect of ethinylestradiol and cyproterone acetate in treatment of polycystic ovarian syndrome. Methods In 112 PCOS patients in our department from 2011 June ～2014 year in June weretaken ethinylestradiol and cyproterone acetate treatment analysis，Before and after treatment were observed by volume， menstrual changes and LH，FSH， E2， T， PRL， ovarian and follicular changes were observed after treatment. Result After treatment， 107 cases recovered by amount， period of 30.6 + 4.3d， there was significant difference than before treatment（P0.05）After treatment， LH， FSH， E2， T， PRL levels were decreased compared with those before treatment， with LH， FSH， T levels decreased significantly， E2 and PRL levels had no obvious change； After the treatment of ovarian volume and the number of follicles than before treatment significantly smaller， less. Conclusion Ethinylestradiol and cyproterone acetate can effectively improve the PCOS patients with clinical symptoms and endocrine， plays an important role in the restoration ofthe menstrual cycle and ovulation， is an ideal drug for treatment of PCOS， and is worthy of clinical use. 　　[Key words] Ethinylestradiol and cyproterone acetate；Polycystic ovary syndrome 　　多囊卵巢综合征（PCOS）是生育年龄妇女常见的由多种病因导致内分泌与代谢功能异常而引起的病症[1]，也是导致妇女不孕的主要原因。PCOS患者由于分泌雄激素过多导致月经紊乱、体重增加、双卵巢增大，影响卵巢功能，从而引起持续性排卵障碍或不排卵，据临床报道[2]，排卵障碍或不排卵是不孕症发生的重要因素，占25%～30%。无排卵性不孕者70～75%与多囊卵巢综合征有关[3]。因此，诱导其排卵，恢复正常月经成为提高治疗效果的关键。现将该科2011年6月―2014年6月收治的112例多囊卵巢综合症患者采用炔雌醇环丙孕酮治疗，取得满意效果，现报道如下。 　　1 资料与方法 　　1.1