慢阻肺急性发作期血清炎性指标的变化研究.docVIP

慢阻肺急性发作期血清炎性指标的变化研究 　　[摘要] 目的 探讨慢性阻塞性肺疾病（COPD）急性发作期患者体内炎性因子的变化及其与疾病发展的关系。 方法 以该院2011年1月―2013年1月间收治的80例COPD患者为观察组，将该院同期进行的80例健康体检者作为对照组，比较两组患者炎性细胞因子和病情监测指标的差异及相关性。结果 观察组患者各炎性细胞因子含量高于对照组，其差异有统计学意义（P0.05）。在COPD患者中，炎性因子与病情监测指标间呈现线性关系。 结论 在COPD急性发作期患者体内各炎性因子含量是上升的，且其于COPD的病情发展程度有关，可作为临床诊断与监测指标，具有积极意义。 　　[关键词] 慢性阻塞性肺疾病；急性发作期；炎性因子 　　[中图分类号] R245 [文献标识码] A [文章编号] 1674-0742（2014）01（a）-0011-02 　　Study on the Changes of Serum Inflammatory Cytokines in the Acute Phase of COPD 　　ZHAO Yonggang 　　Emergency Department， Zhangjiagang First Peoples Hospital， Zhangjiagang， Jiangsu Province， 215600， China 　　[Abstract] Objective To investigate the correlation between the changes of inflammatory cytokines of patients with COPD during the acute phase of COPD and the development of the disease. Methods 80 patients with COPD admitted in our hospital from January， 2011 to January， 2013 were selected as the observation group， and 80 healthy subjects underwent health examination in our hospital during the same period were selected as the control group. The difference and correlation of level of inflammatory cytokines and the monitoring indicators of COPD were compared between the two groups. Results The level of inflammatory cytokines in the observation group were higher than that in the control group， the difference was statistically significant（P0.05）. In COPD patients， there was a linear relationship between the inflammatory cytokines and disease monitoring indicators. Conclusion The level of inflammatory cytokines would rise in the patients with COPD during the acute phase， and there was a significant correlation between the inflammatory cytokines and the development level of COPD. We can use the date changes of inflammatory cytokines as the indicators of clinical diagnosing and monitoring of COPD. 　　[Key words] COPD； Acute phase； Inflammatory cytokines 　　慢性阻塞性肺疾病（COPD）是一种慢性气道炎症疾病，呈进行性发展，患者的气道受限情况有时不可逆，患者预后不良[1]。根据世界卫生组织公布的数据，COPD已经成为造成疾病负担的重要因素[2]，且该病的发病率正在呈现逐年上升趋势[3]。目前，对于COP