支气管哮喘患者血清IL―33水平的变化及临床意义分析.docVIP

支气管哮喘患者血清IL―33水平的变化及临床意义分析 　　[摘要] 目的 分析支气管哮喘患者血清IL-33水平的变化及临床意义。 方法 选择本院收治的64例支气管哮喘患者为观察组，另选择同期于本院行健康体检的60例健康者为对照组，分别对两组对象的血清IL-33水平进行检测，并检测观察组患者的血清IgE及肺功能指标水平。对比和分析两组血清IL-33表达水平及观察组不同病情特点及严重程度的IgE及肺功能指标水平。 结果 观察组的血清L-33水平高于对照组（P0.05）。观察组中急性发作期的血清L-33水平高于临床控制期（P0.05），重度患者的血清L-33水平高于轻度和中度患者（P0.05）。观察组中急性发作期的血清IgE水平高于临床控制期（P0.05），重度患者血清IgE水平高于轻度和中度患者（P0.05）。观察组中急性发作期的FEV1、FEV1/FVC、FEV1% pre均低于临床控制期（P0.05），重度患者FEV1、FEV1/FVC、FEV1% pre均低于轻度和中度患者（P0.05）。观察组IL-33水平与IgE水平呈正相关（P0.05），与FEV1、FEV1/FVC、FEV1% pre均呈负相关（P0.05）。 结论 IL-33可能参与支气管哮喘的发生、发展，通过检测其水平变化有利于判断患者的肺功能及病情。 　　[关键词] 支气管哮喘；IL-33；IgE；肺功能 　　[中图分类号] R562.2+5 [文献标识码] A [文章编号] 1674-4721（2014）09（c）-0103-03 　　Level change and clinical significance analysis of serum IL-33 in patients with bronchial asthma 　　GUO Lu-sheng 　　People′s Hospital of Suichuan County in Jiangxi Province，Suichuan 343900，China 　　[Abstract] Objective To analyze the level change and clinical significance of serum IL-33 in patients with bronchial asthma. Methods Sixty-four patients with bronchial asthma admitted into our hospital were selected and classified into observation group，and another 60 health people for physical examination in our hospital in the same period were categorized into control group.Level of serum IL-33 in the two groups was tested and serum IgE and pulmonary function index in observation group was determined respectively.Expression level of serum IL-33 in the two groups and IgE and pulmonary function index at different state of illness and severity in observation group was compared and analyzed respectively. Results The level of serum IL-33 in observation group was higher than that in control group（P 　　[Key words] Bronchial asthma；IL-33；IgE；Pulmonary function 　　支气管哮喘（bronchial asthma，BA）是呼吸道疾病中的常见病、多发病，临床主要表现为反复发作性咳嗽、呼吸困难、喘鸣等，重者引发呼吸骤停，危及生命。目前，我国BA患者约有3000万人，儿童发病率高达3%，且呈逐年上升趋势，成为威胁人们身心健康及生活质量的重要疾病因素[1]。深入分析BA的发病机制，予以BA高危人群有效的防控干预是降低疾病危害、提高患者生存质量的关键。临床上，BA是由多种细胞因子和炎症介质共同作用而致，病理机制尚未明确。近年来，随着临床医学不断深入地研究BA发病机制，普遍认为气道炎症及气道高反