曲安奈德球周注射联合激光治疗糖尿病性黄斑水肿的疗效研究.docVIP

曲安奈德球周注射联合激光治疗糖尿病性黄斑水肿的疗效研究 　　[摘要] 目的 探讨曲安奈德球周注射联合激光治疗糖尿病性黄斑水肿的疗效。 方法 选择2012年1月～2014年1月我院收治的糖尿病性黄斑水肿患者48例（60眼），全部入选病例随机分为观察组（n=26，30眼，曲安奈德球周注射联合激光治疗）和对照组（n=22，30眼，激光治疗），比较两组的视力改善情况、FFA检查结果及两组患者治疗前及治疗后1、3、6个月黄斑中心凹视网膜厚度的变化。 结果 观察组30只患眼视力提高率达73.33%，显著高于对照组，差异具有统计学意义（χ2=6.357，P0.05）。观察组30只患眼水肿未退率3.3%，显著低于对照组，差异具有统计学意义（χ2=7.386，P0.05）。治疗1、3、6个月后，两组患者黄斑中心凹视网膜厚度分别较治疗前显著降低（P0.01），且观察组较对照组降低更显著（P0.01）。 结论 曲安奈德球周注射联合激光治疗糖尿病性黄斑水肿可有效地提高视力，减轻黄斑水肿程度，安全性好，值得推广和应用。 　　[关键词] 糖尿病性黄斑水肿；曲安奈德；球周注射；激光治疗 　　[中图分类号] R774.5 [文献标识码] B [文章编号] 1673-9701（2014）33-0042-03 　　[Abstract] Objective To investigate the effect of triamcinolone acetonide retrobulbar injection combined with laser photocoagulation for diabetic macular edema. Methods From January 2012 to January 2014 in our hospital，selected 48 cases（60 eyes） patients with diabetic macular edema，and they were randomly divided into observation group（n=26 cases，30 eyes， triamcinolone acetonide combined laser treatment of periocular injection） and control group （n=22 cases， 30 eyes， laser treatment），the changes of vision improvement situation， FFA examination results， and two groups of patients before treatment and after 1，3，6 months of foveal retinal thickness were compared between two groups. Results In the observation group， 30 eyes of the visual acuity improvement rate was 73.33%， significantly higher than the control group（χ2=6.357，P0.05）. The observation group 30 eyes edema without return rate of 3.3%， was significantly lower than the control group（χ2=7.386，P0.05）. Treatment of 1，3， 6 months later，two groups of patients with macular fovea thickness centers decreased significantly（P0.01）， and the observation group decreased more significantly than the control group（P0.01）. Conclusion Triamcinolone peribulbar injection combined with laser for diabetic macular edema effectively improve visual acuity，relieve the degree of macular edema，the security is good， worthy of promotion and application. 　　[Key words] Diabetic macular edema； Cu