Methanecoloncancerabstract.docVIP

J Clin Gastroenterol.?2013 Jan;47 1 :45-51. doi: 10.1097/MCG.0b013e座机电话号码01. Colonic?methane?production modifies gastrointestinal toxicity associated with adjuvant 5-fluorouracil chemotherapy for colorectal?cancer. Holma R,?Korpela R,?Sairanen U,?Blom M,?Rautio M,?Poussa T,?Saxelin M,?Osterlund P. Institute of Biomedicine, University of Helsinki, Helsinki, Finland. Abstract GOALS: To investigate the association of colonic?methane, formed by methanogenic achaea, and pH with gastrointestinal symptoms during colorectal?cancer?chemotherapy. BACKGROUND: Adjuvant 5-fluorouracil chemotherapy reduces recurrences in colorectal?cancer, but causes severe gastrointestinal toxicity, partly related to disturbed intestinal microbiota. STUDY: Resected colorectal?cancer?patients n 143 were analyzed for colonic methanogenesis and pH before and during the 24 weeks of 5-fluorouracil chemotherapy and for gastrointestinal symptoms during chemotherapy. This study was performed within the setting of an intervention study on the effects of Lactobacillus on chemotherapy-related gastrointestinal toxicity. The site of resected?cancer, resection type, stoma, chemotherapy regimen, hypolactasia, and Lactobacillus intervention were considered as possible confounding factors, and multivariate models were constructed. RESULTS: Baseline?methane?producers had less frequent diarrhea more than or equal to moderate during chemotherapy than nonproducers [odds ratio OR , 0.42; 95% confidence interval CI , 0.20 to 0.88; P 0.022] and more frequent constipation OR, 4.56; 95% CI, 2.01 to 10.32; P 0.001 . Baseline fecal pH was also associated with symptoms during chemotherapy; higher the pH, the lower the risk of diarrhea OR, 0.56; 95% CI, 0.31 to 1.02; P 0.058 and higher the risk of constipation OR, 2.23; 95% CI, 1.35 to 3.68; P 0.002 . In multivariate stepwise models, methanogenesis was a significant explaining factor with inverse association with diarrhea and positive association with constipation.