万乃洛韦联合咪唑斯汀治疗玫瑰糠疹的临床研究.docVIP

万乃洛韦联合咪唑斯汀治疗玫瑰糠疹的临床研究 摘要：目的：观察万乃洛韦联合咪唑斯汀治疗玫瑰糠疹的临床疗效。方法：将105例患者随机分为两组，治疗组58例采用万乃洛韦片300mg，2次/d，咪唑斯汀缓释片10mg，1次/d，复合维生素B片3片，3次/d，连续给药10天。对照组47例仅给予咪唑斯汀缓释片、复合维生素B片治疗。两组均于治疗结束后1周判定疗效。结果：治疗组有效率为93.10%，明显优于对照组61.70%，两组比较差异有显著性意义（P 0.01），两组均无严重不良反应。结论：万乃洛韦联合咪唑斯汀治疗玫瑰糠疹疗效显著，疗程短，且使用安全，值得临床应用。 关键词：万乃洛韦 咪唑斯汀 玫瑰糠疹 Doi：10.3969/j.issn.1671-8801.2013.07.006 Valacyclovir combined with mizolastine in the treatment of pityriasis roseaThe clinical study Zhang Ying Li Weiqiang Liang Huipeng Abstract：Objective： To observe the clinical efficacy of valacyclovir combined with mizolastine in the treatment of pityriasis rosea.Methods： 105 patients were randomly divided into two groups，the treatment group of 58 cases with valaciclovir tablets 300mg，2 times /d，mizolastine sustained-release tablets 10mg，1 times /d，compound vitamin B tablets 3 tablets，3 times /d，continuous administration for 10 days.Control only received mizolastine sustained-release tablets，compound vitamin B tablets treatment group of 47 cases.The two groups were to judge the curative effect after treatment of 1 weeks.Result： The effective rate of the treatment group was 93.10%，significantly higher than that of the control group was 61.70%，there was significant difference between the two groups （P 0.01），two groups had no serious adverse reactions.Conclusion： Valacyclovir combined with mizolastine in the treatment of pityriasis rosea obvious curative effect，short course of treatment，and the use is safe，is worthy of clinical application. Keywords：Universal Luo Wei mizolastine Pityriasis rosea 【中图分类号】R4 【文献标识码】A 【文章编号】1671-8801（2013）07-0007-01 玫瑰糠疹是一种具有特征性皮损的炎症性自限性皮肤病，临床表现为躯干及四肢发生椭园形，玫瑰色或黄褐色斑疹，表面覆盖糠秕样鳞屑，一般持继6～8周自愈，也有经久不愈者，病因尚不明确，多认为与病毒感染有关，近期研究表明细胞免疫与本病的发生有关，春秋季节好发，多见于中青年，病程较长，少数患者可迁延半年以上，给患者造成较大的心理负担，传统治疗欠佳，笔者自2011年6月至2013年6月采用口服万乃洛韦联合咪唑斯汀片治疗玫瑰糠疹，取得了较好的疗效，现将观察结果报告如下： 1 资料与方法 1.1 临床资料。105例患者均来自本科门诊部，临床符合玫瑰糠诊诊断标准。实验室检查排除二期梅毒，病检排除付银屑病，且同意按受本项试验对本剂既往无过敏史，非妊娠及哺乳期妇女，1个月内未接受过皮质类固醇及免疫抑制剂治疗，实验室检查无异常者。其中男60例，女45例；年龄14～45岁，平均24.2岁；病程均≤10天，患者随机