三光气法合成新苯并异噻唑啉酮类衍生物.doc

三光气法合成新型苯并异噻唑啉酮类衍生物 王向辉，杨建新，林强＊ 海南大学热带生物资源教育部重点实验室 海南 海口 570228 海南省海口市人民大道58号海南大学理工楼209 摘 要：通过烷基醇与固体三光气（BTC）反应后加入1,2-苯并异噻唑啉-）酮苯并异噻唑啉-）酮[1] Kluschanzoff H, Lehmann R, Leinen H T. Mixtures of active anti-microbial substances[P]. DE: 4 217 881, 1993-12-02. [2] Eggensperger H, Oltmanns P, Scheler K H, et al. Liquid 1,2-benzoisthiazoline-3-one preparation[P]. US: 5 276 047, 1994-01-04. [3] Payne J D. Stable liquid compositions and their use[P].WO: 9 416 564, 1994-08-04. [4] Austin P W.N- beta-branched alkyl -1,2-benzisothiazolin-3-ones,their preparation and use as industrial biocides[P]. WO: 9 420 479, 1994-09-15. [5] 江川均.工业用杀菌组成物[P]. JP: 06 305 917, 1994-11-1. [6] Hiraiwa S, Nakano T, Suzuki K, Nakao H. Antifungal and waterproof fabric and its production[P].JP: 06 313 269, 1994-11-08. [7] Lewis S N, Miller G A, Law A B. Certain 2-carbamoyl-3-isothiazolenes: US, 座机电话号码[P]. 1970-04-08. [8] Collier P J, Ramsey A J, Austin P, et al. Growth inhibitory and biocidal activity of some isothiazolone biocides[J]. J Appl Bacteriol, 1990,69:569-577. [9] Bordi F, Mor M, POLazzi P V, et al. 4- 1,2-benzisothiazol-3-yl alkanoic and phenyl alkanoic acids: synthesis and anti-inflammatory, analgesic and antipyretic activities[J]. Farmaco, 1992, 47 5 : 551-565. [10] Paola V, Loredana A, Vigilio B, et al. 2-amino-benzo[d]isothiazol-3-one derivatives: synthesis and assessment of their antipolatelet/spasmolytic effects[J]. Bioorg. Med. Chem., 2000 8 : 2355-2358. [11] Vigilio B, Massimiliano T. New insights into the parmacological properties of potent antiPOLatelet 2-amino-benzo[d]isothiazol-3-one derivatives[J]. Pharmacol. Res., 2002, 46 5 : 389-393. [12] Eacho P Z, Foxworthy-Mason P S, Lin H S. Preparation of oxobenzisothiazole carbox-amides as phospholipase inhibitors: WO座机电话号码4[P]. 2004-11-04. [13] 邢凤兰,徐群,徐孙见.三光气代替光气合成系列化合物的研究和应用[J].精细与专用化学品，2006,14 21）:11-15. [14] 陈年春.农药生物技术测定[M].北京:北京农业大学出版社，1991:161. 三光气法合成新型苯并异噻唑啉酮类衍生物 王向辉，杨建新，林强＊ 海南大学热带生物资源教育部重点实验室 海南 海口 570228 海口市人民大道58号海南大学理工楼209