阿托伐他汀对急冠脉综合征患者血清MMP22 及TIMP22 的作用.doc

阿托伐他汀对急性冠脉综合征患者血清MMP-9 MMP-2 及hs-CRP 的影响 摘要: 目的: 研究应用阿托伐他汀(atuovastatin) 对急性冠脉综合征(acute coronary syndromes ACS) 患者血清MMP-9 MMP-2 hs-CRP 的影响。方法: 选定ACS 患者61 例,稳定型心绞痛(SA) 患者19 例及正常对照组30 例。随机将ACS 患者分为阿托伐他汀组(33 例) 和常规组(28 例) ,比较各组间血清MMP-9 MMP-2 及hs-CRP的水平变化。结果: ACS 组与SA 组及正常对照组之间血清MMP-9 MMP-2 及hs-CRP水平相比差异有统计学意义,两组干预后血清MMP-9 MMP-2、及hs-CRP水平相比差异有统计学意义。结论: 阿托伐他汀可降低ACS 患者血清MMP-9 MMP-2及 hs-CRP 水平, 减少冠状动脉粥样斑块基质成分的降解和炎症反应,从而起到稳定动脉粥样硬化斑块的作用。关键词: 急性冠脉综合症; 基质金属蛋白酶2 ; 基质金属蛋白酶9 ; 高敏C反应蛋白︰阿托伐他汀 The effect of atuovastatin on serum level of matrix metallopro teinase-9 matrix metallopro teinase-2 and High sensitivity C-reactive protein patients with acute coronary syndrome Abstract : Objective : To investigate the influences of atuovastatin on serumMMP-9 MMP2 , and hs-CRP levels of patients with acute coronary syndrome (ACS) . Methods : There were 61 patients with ACS and 19 patients with SA. Meanwhile , 30 cases of age matched control individuals wereselected. Then 61 patients with ACS were randomly divided into two groups : atuovastatin treatmentgroup and regular treatment group. The serum level of MMP-9 MMP–2 and hs-CRP were compared among all groups. Results : There was significant difference in serum level of MMP-9 MMP–2 and hs-CRP between ACS group and SA group and control group. There was significant difference in serum level of MMP-9 MMP–2 and hs-CRP between atuovastatin treatment group and regular treatment group after treatment . Conclusion : atuovastatin could decrease the breakdown of matrix collagen and reduce inflammatory reaction , and it might have a beneficial effect on steadying the plaque. Keywords : ACS; MMP–2 ;MMP-9 ;hs-CRP atuovastatin 　急性冠状动脉综合征（ACS）是引起冠心病患者死亡及致残的主要原因各种致炎因素导致的炎症反应破坏冠状动脉斑块纤维帽的稳定性，使斑块发生破裂、出血，继而血栓形成是ACS发生的主要原因。MMP-9　MMP-2在冠脉斑块破裂区域表达的增强,主要通过降解细胞外基质而削弱纤维帽促进斑块破裂[ 1] ,而导致冠心病的发生发展。hs-CRP是体内炎症反应的标记 ，可作为血管炎症的标记物，是心血管疾病的独立的危险的因素。本研究通过随机、对照的方法,在ACS 患者应用阿托伐他汀干预前后测定其血清MMP-9、 MMP-2 及hs-CRP水平的变化,探讨阿托伐他汀干预对ACS 患者减少炎症反应及稳定斑块的影响。 1 　对象和方法 1. 1 　研究对象　选择