高脂血症胰腺炎摘要.docVIP

Summary Clinical Lipidology October 2013, Vol. 8, No. 5, Pages 587-594 , DOI 10.2217/clp.13.44 doi:10.2217/clp.13.44 Review Hypertriglyceridemia-induced acute pancreatitis Nils Ewald?? Hypertriglyceridemia is a well established cause of acute pancreatitis and accounts for up to 10% of all acute pancreatitis cases and even up to 50% of all acute pancreatitis cases in pregnancy. Hydrolysis of triglycerides by pancreatic lipase and excessive formation of free fatty acids with inflammatory changes, capillary injury and hyperviscosity are postulated to account for the development of hypertriglyceridemia-induced pancreatitis HTGP . The clinical features of those patients are generally no different from patients with acute pancreatitis of other etiologies. HTGP, however, seems to be associated with a higher severity and complication rate. There is no clear evidence as to which hypertriglyceridemia patients will develop acute pancreatitis and which will not. Insulin, heparin, plasmapheresis and different antihyperlipidemic agents, as well as dietary modifications, are key features in the management of HTGP. Annals of Surgery: May 2013 - Volume 257 - Issue 5 - p 943–951 doi: 10.1097/SLA.0b013e318269d536 Original Articles Fat Necrosis Generates Proinflammatory Halogenated Lipids During Acute Pancreatitis Franco-Pons, Neus PhD*; Casas, Josefina PhD?; Fabriàs, Gemma PhD?; Gea-Sorlí, Sabrina PhD*; de-Madaria, Enrique MD, PhD?; Gelpí, Emilio PhD*,§; Closa, Daniel PhD* Abstract Objective: To evaluate the generation of halogenated fatty acids in the areas of fat necrosis during acute pancreatitis and to evaluate the effects of these molecules on the ensuing inflammatory process. Background: Lipid mediators derived from adipose tissue have been implicated in the progression of acute pancreatitis, although their precise role remains unknown. Methods: Acute pancreatitis was induced in rats by intraductal infusion of 3.5% sodium taurocholate. Fatty acid chlorohydrins FA-Cl were me