ChromatinRemodeling题材.ppt

Chromatin Remodeling Chromatin Remodeling Activation of many eukaryotic genes requires chromatin remodeling Several protein complexes carry this out All have ATPase harvesting energy from ATP hydrolysis for use in remodeling Remodeling complexes are distinguished by ATPase component Remodeling Complexes SWI/SNF In mammals, has BRG1 as ATPase 9-12 BRG1-associated factors (BAFs) A highly conserved BAF is called BAF 155 or 170 Has a SANT domain responsible for histone binding This helps SWI/SNF bind nucleosomes ISWI Have a SANT domain Also have SLIDE domain involved in DNA binding Mechanism of