培训课件--骨关节疾病病理学.pptVIP

When osteoarthritis strikes in youth, there is typically some predisposing condition, such as previous traumatic injury, developmental deformity, or underlying systemic disease such as diabetes or marked obesity. In these settings the disease is called secondary osteoarthritis and often involves one or several predisposed joints. The earliest structural changes in osteoarthritis include enlargement, proliferation, and disorganization of the chondrocytes in the superficial part of the articular cartilage. Subsequently, vertical and horizontal fibrillation and cracking of the matrix occur a