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(continue) ? We thank the reviewer for having paid a good deal of attention to that kainate (KA) has been used as a powerful tool to evaluate pharmacological and mechanistic properties of glutamate receptors. Indeed, KA, as an agonist for the AMPA/KA class of glutamate receptor, is widely used to induce status epilepticus and kindling. Using these models of epilepsy, neurobiologists have well defined patterns of neuronal degeneration in the hippocampus and other brain regions. Neuronal alterations in KA-induced seizures have widely been investigated by testing hippocampal hyperexcitability, cI