肝脏实时组织弹性成像评分与肝纤维化四项指标相关性的探讨_杜阳春.docxVIP

148Guangxi Medical Journal，Feb． 2012，Vol． 34，No． 2肝脏实时组织弹性成像评分与肝纤维化四项指标相关性的探讨▲杜阳春1廖新红1杨红1秦雪2姜海行3江建宁4( 广西医科大学第一附属医院 1 超声科，2 检验科，3 消化内科，4 感染科，南宁市530021; E-mail: 247977317@ qq． com)【摘要】 目的 探讨实时组织弹性成像( RTE) 评分与血清肝纤维化四项指标评价慢性乙型肝炎、乙肝肝硬 化患者肝纤维化程度的相关性。方法 选择慢性乙型肝炎、乙型肝炎肝硬化患者 62 例，均常规超声扫查后行 RTE 检查，图像根据弹性程度分为 0 ～ 4 分，将 RTE 评分与纤维化指标［Ⅲ型前胶原氨基末端肽( PⅢNP) 、透明质酸 ( HA) 、Ⅳ型胶原( CIV) 、层粘连蛋白( LN) ］进行对比分析。结果 RTE 评分随纤维化指标水平的升高而增加，不 同评分组各指标水平比较差异有统计学意义( P ＜ 0． 05) 。RTE 评分与纤维化指标水平呈正相关( P ＜ 0． 01) 。 结论 RTE 技术为诊断肝纤维化提供了新手段，有望成为客观评价肝纤维化程度的无创检查方法。【关键词】 肝纤维化; 实时组织弹性成像; 血清学【中图分类号】 R 575; R 512． 6【文献标识码】 A【文章编号】 0253-4304( 2012) 02-0148-03Investigation on the Correlation between Real-time Tissue Elastography and Four Indexes of Serum Liver FibrosisDU Yang-chun1 ，LIAO Xin-hong1 ，YANG Hong1 ，QIN Xue2 ，JIANG Hai-xing3 ，JIANG Jian-ning4( 1 Department of Ultrasound，2 Department of Inspection，3 Department of Gastroenterology，4 Department of Infectious Diseases，the First Affiliated Hospital of Guangxi Medical University，Nanning 530021，China)【Abstract】 Objective To investigate the correlation between real-time tissue elastography ( RTE) and four indexes of serum liver fibrosis in patients with chronic hepatitis B or hepatitis B cirrhosis． Methods Sixty-two patients with chronic hepatitis B or hepatitis B cirrhosis were enrolled in the study，and they all received routine ultrasound and RTE examination． The elasticity scores ranged from 0 to 4． A comparative analysis was done between elasticity scores and the indexes of serum liver fibrosis including procollagenⅢ N-terminal peptide( PⅢNP) ，hyaluronic acid( HA) ， collagen type Ⅳ( CIV) and laminin( LN) ． Results The elasticity scores increased when the levels of serum liver fibrosis indexes increased． There were significant differences in levels of the four indexes among different-score groups( P ＜ 0． 05 ) ． The elasticity scores correlated positively with the levels of serum liver fibrosis indexes( P ＜ 0． 01 ) ．Conclusion RTE provides a new method for the diagn