培训课件--儿童缺铁与缺铁性贫血.pptVIP

* Haem iron is taken up by the haem iron transporter (HCP), undergoes endocytosis, and Fe2+ (ferrous iron) is liberated within the endosome or lysosome. Non-haem iron includes Fe2+ and Fe3+ (ferric iron) salts. Fe3+ is reduced to Fe2+ by ascorbic acid in the lumen or by membrane ferrireductases that include duodenal cytochrome B (DCYTB). At the apical membrane, the acid microclimate provides an H+ electrochemical gradient that drives Fe2+ transport into the entercyte via the divalent metal-ion transporter (DMT1). At the basolateral membrane, iron transport to transferrin in the circulation is