气体信号分子硫化氢的究进展.docVIP

气体信号分子硫化氢的研究进展 罗慧琴 林健清 【摘要】：背景 硫化氢(hydrogen sulfide, H2S)长期以来一直被视为是一种有毒废气，近年来的研究表明， H2S作为最新发现的内源性气体信号分子，具有重要的生物学活性，广泛参与机体多种生理、病理过程H2S的生理病理以及与疾病的关系，并就其研究进展作一综述。 内容 H2S不仅对全身多系统的缺血性等疾病有治疗作用，对神经性及炎症性疼痛的双向性调节作用更是关系密切，其机制可能与其是内源性血管平滑肌的KATP通道开放剂及具有抗氧化作用相关。趋向 H2S这些新用途对探寻临床相关疾病的有效治疗方法具有重要意义，未来研究重点应在H2S对于疼痛作用的确切机制上。 【关键词】：H2S；气体信号分子；作用机制 Research progress of gaseous signal molecule hydrogen sulfide LUO Hui-qin, LIN Jian-qing. Department of Anesthesiology, First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, China 【Abstract】 Background Hydrogen sulfide (H2S) has been regarded as a noxious gas for a long time, Studies in recent years have shown that H2S acts as the new discovered endogenous gas signal molecule at present, which has important biological activity and take part in many physiological and pathological processes widely in the body. Objective To discuss the relation between the physiology and pathology effect of gaseous signal molecules H2S and diseases, and provides a detailed description of the H2S research processes. Content H2S not only has therapeutic effects on ischemic diseases of the systemic multisystem, but also has two phases influence on neuropathic and inflammatory pain. The mechanism might be related to that H2S is endogenous vascular smooth muscle KATP channel openers and it has antioxidant activity. Trend These new uses of H2S have important significance for exploring the effective method in related clinical diseases. Future work should be emphasized on the precise mechanism of H2S for the pain. 【Key words】 Hydrogen sulfide; Gaseous signal molecule; Mechanism of action （hydrogen sulfide，H2S）(nitric oxide，NO)和(carbon monoxide，CO)（ischemia/reperfusion injury，I/RI）H2S的生理病理及其相关的基础和临床研究方面的进展，以及对机体各系统的生物学作用。 1. H2S的生理 在哺乳动物组织中，产生内源性H2S的酶有三种：胱硫醚β-合成酶（cystathionine β-synthase，CBS）γ-裂解酶（cystathionine γ-lyase，CGL or CSE）(3-mercaptopyruvate sulfur transferase，3MST)CBS在大脑组织的表达最高，CSE主要分布于各种血管组织，3MST在红细胞中活性较强，而在肝、肾、胰腺和胃肠道组织中这三种酶含量都很丰富。CB