前列腺和精囊的分子生物学,内分泌学和生理学.ppt

Development, Molecular Biology, Endocrinology, and Physiology of the Prostate Yu Meng 2015.08.19 Content Endocrinology Prostatic Secretions 3 Development and Cell Biology 1 2 Physiology 4 Seminal vesicles Origin: mesonephric duct Steroid: testosterone Feature: extremely resistant to disease Prostate Origin: urogenital sinus epithelium and mesenchyme Steroid: dihydrotestosterone DHT Feature: mesenchymal condensation Stromal-epithelial interactions Prostate cell types Content Endocrinology Prostatic Secretions 3 Development and Cell Biology 1 2 Physiology 4 Androgen Production by the Testes Major source：Leydig cells Concentration：611ng/100mL (10.4-34.7nmol/L) in the plasma 40-50ug/mL in the spermatic vein(75 times) Adrenal androgens Dehydroepiandrosterone(DHEA) Androstenedione Less than 1% of the total testosterone in the plasma is derived from DHEA Androstenedione cannot be converted directly to DHT. An important role for androstenedione in the male may be its peripheral conversion to estrogens through the aromatase reaction. insignificant Androgen-Binding Proteins in the Plasma TeBG 57% HSA 40% CBG 1% (1) the affinity of the steroid to bind to a specific protein (2) the capacity, which is the maximal potential binding when all of a binding protein is saturated with bound steroid; the capacity is governed by the amount of binding protein in the plasma Hormone therapy Regulation of Prostate Growth Androgen Action at the Cellular Level Androgen Receptors Location: the long arm of the X chromosome at position Xq11.2-q12. AR is a member of the nuclear receptor superfamily which share certain structural features that allow them to regulate gene expression. Mechanism of androgen recep