2015药物研发与生产过程中质量控制新理念和新技术.pptVIP

BCS是什么? 渗透性与溶解度的分类 * 生物药剂类型 I II III IV 溶解度 High Low High Low 渗透性 High High Low Low Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile . Copyright 2004-2011 Aspose Pty Ltd. 近端人类胃肠道模拟液汁 模拟胃液 Fasted (FaSSGF) Na taurocholate Lecithin Pepsin NaCl HCl, pH 1.6 121 mOsm/kg Fed (FeSSGF) Early NaCl Milk/buffer HCl/NaOH, pH 6.4 559 mOsm/kg Middle NaCl HoAc NaoAc Milk/buffer HCl/NaOH, pH 5 500 mOsm/kg Late NaCl H3PO4 NaH2PO4 Milk/buffer HCl/NaOH, pH 3 300 mOsm/kg 模拟肠汁 Fasted (FaSSIF) Na taurocholate Lecithin Maleic acid NaCl NaOH, pH 6.5 180 mOsm/kg Fed (FeSSIF) Na taurocholate Leci