第五章 抗溃疡药【参考】.pptVIP

Structure Characteristics 苯并咪唑环 吡啶环 联结的亚磺酰基 奥美拉唑的光学活性 左旋体有活性，药用外消旋体 Synthesis Physical and Chemical Properties ◆ 水溶液中不稳定，对强酸也不稳定， ◆ 应低温避光保存 弱酸性 弱碱性 Physical and Chemical Properties Omeprazole is a white to off-white crystalline powder which melts with decomposition at about 155°C. It is a weak base, freely soluble in ethanol and methanol, and slightly soluble in acetone and isopropanol and very slightly soluble in water. The stability of Omeprazole is a function of pH; it is rapidly degraded in acid media, but has acceptable stability under alkaline conditions. 制剂 Preparations ◆ 一般作成肠