我国艾滋病抗病毒治疗标准调整前后治疗病人生存情况研究.docVIP

我国艾滋病抗病毒治疗标准调整前后治疗病人生存情况研究 曾亮1，马烨1，豆智慧1，赵德才1，张福杰1.2 （1.中国疾病预防控制中心 性病艾滋病预防控制中心，北京 102206； 2.首都医科大学附属北京地坛医院 北京 100015 ） 摘要：目的 比较我国艾滋病抗病毒治疗标准调整前后接受抗病毒治疗的成年HIV）感染者/艾滋病（AIDS）病人HIV/AIDS病人的生存状况及探讨影响因素。方法 通过国家艾滋病抗病毒治疗综合防治信息系统，收集病人的基线情况和随访信息，计算病死率以及运用生存曲线和建立COX比例风险回归模型进行分析。结果 共收集到开展抗病毒治疗的HIV/AIDS病人270 313例，其中2008年及以前入组的病人5年累计生存率为0.79入组的病人5年累计生存率为0.85入组的病人3年累计生存率大于0.90。多因素COX回归结果显示治疗标准调整年份≤2008年开始抗病毒治疗者的死亡风险开始抗病毒治疗者的1.28倍，除此之外，性别、年龄、婚姻状况、感染途径、药物治疗方案均影响病人死亡。结论 艾滋病抗病毒治疗标准调整后，使得更多的HIV/AIDS在免疫水平较高时开始接受抗病毒治疗，对降低病死率，延长生存时间具有重要意义。 : 1672-5662(2016)06-0000-00 Study on the survival of adult HIV/AIDS patients received antiretroviral therapy before and after the adjustment of enrollment criteria Zeng Liang1,Ma Ye1,Dou Zhihui1,Zhao Decai1,Zhang Fujie1,2.(1. Center for STD/AIDS Control and Prevention, China Center for Disease Control and Prevention, Beijing 102206, China; 2. Beijing Ditan Hospital, Capital Medical University) Corresponding author: Ma Ye, Email: maye67@163.com Abstract: Objective To compare the survival of adult HIV/AIDS receiving antiretroviral therapy before and after the adjustment of enrollment criteria and also to explore the related factors. Methods The information on baseline and follow-up of patients was collected from the National HAART reporting system, mortality rates were described and analyzed by survival curve and Cox proportional hazards model. Results A total of 270 313 cases receiving antiretroviral therapy were included in this study. Five-year survival rate of patients enrolled in and before 2008 was 0.79; five-year survival rate of patients enrolled in 2009~2011 was 0.85; three-year survival rate of patients enrolled in 2012-2013 was greater than 0.90. Multivariate Cox proportional hazards model indicated that the risk of death starting antiretroviral therapy in and before 2008 was 1.28 times compared with patients