万拉法新与西酞普兰治疗抑郁症对照研究.docVIP

万拉法新与西酞普兰治疗抑郁症对照研究 作者：杨忠 宋静波 尹建兵 谭文钟 【关键词】 万拉法新；西酞普兰；抑郁症；汉密顿抑郁量表；副反应量表 【摘要】 目的 评价万拉法新与西酞普兰治疗抑郁症的临床疗效及安全性。方法 将65例抑郁症患者随机分为万拉法新组32例，西酞普兰组33例，观察6 w。于治疗前和治疗1 w、2 w、6 w末采用汉密顿抑郁量表评定疗效，副反应量表评定不良反应。 结果 万拉法新组显效率%，西酞普兰组%，两组比较差异无显著性；治疗第1 w末万拉法新组汉密顿抑郁量表评分显著低于西酞普兰组。2 w、4 w、6 w末两组评分比较差异无显著性；万拉法新组不良反应发生率%，西酞普兰组%，两组比较差异无显著性。 结论 万拉法新与西酞普兰治疗抑郁症具有同等疗效，但万拉发新起效较西酞普兰快。 【关键词】 万拉法新；西酞普兰；抑郁症；汉密顿抑郁量表；副反应量表 A control study on venlafaxine vs. citaloparm in the treatment of depression 【Abstract】 Objective To evaluate the clinical curative effects and safety of venlafaxine vs. citaloparm in the treatment of depression. Methods 65 patients with depressive disorder were randomly pided into venlafaxine and citaloparm group for 6 weeks. The curative effects were assessed with the Hamilton Depression Scale and adverse effects with the Treatment Emergent Symptom Scale before treatment and at the ends of the 1st, 2nd and 6th week, respectively. Results Excellence rates were respectively % in venlafaxine and % in the citaloparm group, which showed no significant difference; at the end of the 1st week, score of the HAMD was significantly lower in the venlafaxine than in the citaloparm group. There were no significant differences at the ends of the 2nd, 4th and 6th week between the 2 groups; incidences of adverse effects were respectively % in the venlafaxine and % in the citaloparm group, difference was not significant. Conclusion Venlafaxine has therapeutic equivalence to citaloparm in depression, but takes effects faster. 【Keywords】 Venlafaxine; citaloparm; depression { http://本,资.料/,于/范文.之.家 ) ; the HAMD; the TESS 　　有文献表明［1］，30%的抑郁症患者对各种治疗没有反应，40%～45%的慢性抑郁症患者缺乏治疗反应。且在临床治疗过程中发现，不同的药物有着不尽相同的副作用。为此作者采用万拉法新与西酞普兰进行了对照研究，以探讨万拉法新的临床疗效及安全性，现报告如下。 1 对象与方法 对象 选取XX年5月～XX年5月在我院门诊及住院治疗的65例抑郁症患者为研究对象。入组标准：符合《中国精神障碍分类与诊断标准》第3版抑郁症诊断标准；年龄24 a～81 a；汉密顿抑郁量表评分≥18分；入组1 w前未服用任何抗精神病及抗抑郁药物；排除躯体及脑器质性疾病、双相障碍快速循环型、精神分裂症及妊娠、哺乳期妇女；无酒精或其它活性物质