- 1、本文档共51页,可阅读全部内容。
- 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
查看更多
Chapter 11 Analysis of Antibiotics SECTION 1 GENERAL CONSIDERATIONS There are more than 100 types of Antibiotic drugs and their preparations 1) there are some impurities in general products of antibiotics, fine purified 2)?most of antibiotics are unstable 3) decomposition products of antibiotics are less or no therapeutic efficacy and more side-effect or toxic Besides the limit tests and methods for quantitative determination the procedures of assay are also specified. 1. General examinations for antibiotics: ①? Identification ②??Undue toxicity ③??Sterility ④??Pyrogens ⑤??Water content ⑥??Clarity of solution ⑦??pH value of solution ⑧ Depressor substance ⑨ Assay 2. Assay: Biological or physical-chemical procedure 1) Biological procedure ① the principle comply with the clinical requirement ②?the?sensitivity is high ③ the amount of sample needed for assay is small ④ to estimate the total antibiotic activities 2)?Physical-chemical procedure: ①?the process is more easy than the biological procedures ② the result is more precise and accurate The results may only represent total amount of antibiotics, not bio-potency value Only the results of physical-chemical method are complied with of biological method can it be used in Assay 3. Content of this chapter: 1) ?-lactams 2) Aminoglycosids 3) Tetracyclines Section 2 ?-LACTAM ANTIBIOTICS 1. chemical structure and properties 1) structure ① penicillin Section 2 ?-LACTAM ANTIBIOTICS 1. chemical structure and properties 1) structure ① penicillin Section 2 ?-LACTAM ANTIBIOTICS 1. chemical structure and properties 1) structure ① penicillin RCO-: ② cephalosporin 2) properties ①??acidic action
您可能关注的文档
- ch6_单环芳烃2011课件.ppt
- CH9 数据库完整性与安全_1课件.ppt
- cha5核苷酸和核酸课件.ppt
- Chap.10 取代酸课件.ppt
- CH1 概述(修)园林工程概预算课件.ppt
- Chap.2 radical polymerizatioin-1课件.ppt
- chap18维生素及辅酶类课件.ppt
- Chap1第四节 植物催化系统——酶课件.ppt
- chapt05、 记忆课件.ppt
- chap4.1人的生理特性课件.ppt
- 《JJF 2132-2024荧光紫外灯人工气候老化试验装置校准规范:辐射照度参数》.pdf
- JJF 2120-2024轮速传感器校准规范.pdf
- 计量规程规范 JJF 2120-2024轮速传感器校准规范.pdf
- 《JJF 2129-2024钙钛矿太阳电池校准规范:光电性能参数》.pdf
- JJF 2129-2024钙钛矿太阳电池校准规范:光电性能参数.pdf
- 《JJF 2120-2024轮速传感器校准规范》.pdf
- JJF 2117-2024沥青混合料理论最大相对密度仪校准规范.pdf
- JJF 2116-2024特定蛋白分析仪校准规范.pdf
- 《JJF 2116-2024特定蛋白分析仪校准规范》.pdf
- 计量规程规范 JJF 2117-2024沥青混合料理论最大相对密度仪校准规范.pdf
文档评论(0)