顺式阿曲库铵与罗库溴铵用于全麻气管插管的临床效果分析.docVIP

顺式阿曲库铵与罗库溴铵用于全麻气管插管的临床效果分析 　　[摘要] 目的 探讨顺式阿曲库铵和罗库溴铵分别用于全麻诱导气管插管的效果。 方法 将124例行全麻气管插管腹部手术的患者随机分为顺式阿曲库铵组和罗库溴铵组，各62例，经静脉注入咪达唑仑0.1 mg/kg，芬太尼3 μg/kg进行麻醉诱导，待患者意识和睫毛反射消失后，顺式阿曲库铵组给予顺式阿曲库铵0.15 mg/kg，罗库溴铵组给予罗库溴铵0.6 mg/kg后行气管插管，比较气管插管的总有效率及两组患者诱导前、插管后1、5 min时平均动脉压（MAP）、脉搏氧饱和度（SpO2）、心率（HR）的变化，记录全麻诱导的起效时间、作用时间、恢复指数及组胺释放情况。 结果 罗库溴铵组气管插管总有效率为95.2%，与顺式阿曲库铵组（88.6%）比较差异有统计学意义（χ2=1.74，P 0.05）；两组患者插管后1 min的MAP、HR明显上升（P 0.05），5 min后与诱导前无明显差异；罗库溴铵组的起效时间和作用时间较短，恢复指数也明显低于顺式阿曲库铵组，差异有统计学意义（P 0.05）。 结论 罗库溴铵用于全麻气管插管术的起效时间短，恢复迅速，是临床上较理想的肌松药。 　　[关键词] 气管插管；顺式阿曲库铵；罗库溴铵；起效时间 　　[中图分类号] R614.2 [文献标识码] A [文章编号] 1673-7210（2014）04（a）-0058-03 　　Clinical effect analysis of Cisatracurium and Rocuronium for tracheal intubation general anesthesia 　　TONG Botao SUN Hao XU Xin DUAN Jiafang 　　Department of Anesthesiology， NO.81 Hospital of Chinese Peoples Liberation Army， Jiangsu Province， Nanjing 210002， China 　　[Abstract] Objective To investigate the effect of Cisatracurium and Rocuronium for tracheal intubation of general anesthesia induction. Methods 124 patients who were scheduled for elective surgery and required endotracheal intubation were randomly divided into two groups， with 62 cases in each group， they were given intravenous injection of Midazolam 0.1 mg/kg， Fentanyl 3 μg/kg for anesthesia induction. Then the Cisatracurium group was given Cisatracurium 0.15 mg/kg， and Rocuronium group was given Rocuronium 0.6 mg/kg， Sevoflurane was used to control anesthesia depth after endotracheal intubation. The total effective rate and changes of endotracheal intubation condition， MAP， SpO2 and HR 5 min after intubation in the two groups were compared before endotracheal intubation and after general anesthesia induction. Besides， the clinical onset time， muscle relaxant effect time， muscle recovery index and adverse reactions were also observed. Results Total effective rate of the Rocuronium group （95.2%） for endotracheal intubation was higher than that of the Cisatracurium group （88.6%）， the differen