不同化疗方案对胃癌术后患者的疗效分析.docVIP

不同化疗方案对胃癌术后患者的疗效分析 　　[摘要] 目的 探讨胃癌术后两种化疗方案的效果。 方法 选取2008～2009年在本院进行手术治疗的胃癌患者50例，随机分为两组，其中TPF组25例，给予TPF方案[多烯紫杉醇（TXT）+顺铂（CDDP）+氟尿嘧啶（FU）]进行术后化疗；FOLFOX组25例，给予FOLFOX方案[奥沙利铂（L-OHP）+氟尿嘧啶（FU）+甲酰四氢叶酸（LV）]进行术后化疗，观察比较两组患者的生活质量改善情况、毒副作用、远期生存率。 结果 FOLFOX组患者在生活质量情况、远期生存率方面显著优于TFP组，差异有统计学意义（P0.05）；在毒副作用方面，FOLFOX组患者在血小板减少这一指标上优于TFP组（P0.05）。 结论 TPF方案和FOLFOX方案比较，后者临床疗效好，毒副作用相对少，远期生存率高，值得临床推广。 　　[关键词] 化疗；胃癌；TPF方案；FOLFOX方案 　　[中图分类号] R735.2 [文献标识码] A [文章编号] 1674-4721（2013）11（c）-0045-02 　　Curative effect analysis of different chemotherapy regimens in postoperative gastric cancer patients 　　WANG Min 　　Oncology Department，People′s Hospital of Zongyang County in Anhui Province，Zongyang 246700，China 　　[Abstract] Objective To investigate the treatment efficacy of two kinds of chemotherapy in postoperative gastric cancer patietns. Methods 50 cases of gastric cancer went through surgical treatment from 2008 to 2009 in the author′s hospital were randomly divided into two groups.25 cases in the TPF group were given TPF scheme [docetaxel （TXT）+cisplatin （CDDP）+fluorouracil （FU）] for postoperative chemotherapy；25 cases in the FOLFOX group were given FOLFOX regimen [oxaliplatin （L-OHP）+fluorouracil （FU）+leucovorin （LV）] for postoperative chemotherapy.Improvement IN quality of life，side effects，long-term survival rate of the two groups were observed and compared. Results Quality of life and long-term survival rate of the FOLFOX were significantly better than those of the TFP group （P0.05）；In terms of toxic side effects，FOLFOX group was figinticantly better in thrombocytopenia than the TFP group （P0.05），with little differences in other indicators. Conclusion Compared with TPF regimen，FOLFOX regimen has better clinical efficacy，less toxic effect and higer long-term survival rate，thus is worthy of promotion. 　　[Key words] Chemotherapy；Gastric cancer；TPF regimens；FOLFOX regimens 　　胃癌是最常见的恶性肿瘤之一，死亡率高，位居恶性肿瘤死因的第二位[1-2]。手术为胃癌常用的治疗方法，但其切除率低、复发转移率较高。Ⅲ期胃癌5年生存率低，晚期胃癌中位生存期仅6～10个月。胃癌术后往往需要采用化疗巩固胃癌手术的治