利奈唑胺治疗老年人院内耐甲氧西林金黄色葡萄球菌感染的效果分析.docVIP

利奈唑胺治疗老年人院内耐甲氧西林金黄色葡萄球菌感染的效果分析 　　[摘要] 目的 探讨利奈唑胺治疗老年人院内耐甲氧西林金黄色葡萄球菌感染的效果。 方法90例老年耐甲氧西林金黄色葡萄球菌感染者根据治疗方法的不同分为治疗组与对照组，各45例，治疗组给予利奈唑胺治疗，对照组给予万古霉素治疗。 结果 两组都无死亡患者，治疗组的总有效率为91.1%，对照组总有效率为75.6%，组间差异有统计学意义（P0.05）；两组不良反应发生率差异也有统计学意义（P0.05）。 结论 利奈唑胺治疗老年人院内耐甲氧西林金黄色葡萄球菌感染效果明显优于万古霉素，且安全性更好，有很好的推广价值。 　　[关键词] 利奈唑胺；院内耐甲氧西林金黄色葡萄球菌感染；老年人；万古霉素 　　[中图分类号] R978 [文献标识码] A [文章编号] 1674-4721（2013）11（b）-0094-02 　　The analysis of linezolid for the elderly hospital methicillin-resistant Staphylococcus aureus infections 　　ZHU Lin 　　ICU of the First People′s Hospital of Zhumadian City in Henan Province， Zhumadian 463000，China 　　[Abstract] Objective To investigate the effects of linezolid in treatment of elderly hospital methicillin-resistant Staphylococcus aureus infections. Methods 90 elderly patients with hospital methicillin-resistant Staphylococcus aureus infections were divided into treatment group and control group， with 45 cases in each group， the treatment group was given linezolid therapy， the control group was treated with vancomycin. Results There were no deaths in all patients， the total effective rate of the treatment group was 91.1%， so that was 75.6% in the control group， difference between the two groups was significant （P0.05）. And the incidence of adverse reactions between the two groups was significantly different （P0.05）. Conclusion Effect of linezolid in treatment of elderly patients with hospital methicillin-resistant Staphylococcus aureus infections is better than vancomycin， and the security is good and is suitable for clinical praction. 　　[Key words] Linezolid； Hospital methicillin-resistant Staphylococcus aureus infections； Elderly； Vancomycin 　　随着医疗条件的不断完善以及抢救成功率的提高，各类危重患者的存活率较前明显上升，长期住院患者各种院内感染的发生率日渐增加，且抗感染治疗效果欠佳[1]。耐甲氧西林金黄色葡萄球菌（methicillin-resistance Staphylococcus aureus，MRSA）就是其中很重要的一种，占金黄色葡萄球菌的60%～80%，特别是氟喹诺酮类药物应用于临床后，对其耐药的金黄色葡萄球菌迅速出现，而且90%以上为MRSA[2]。由于MRSA常为多重耐药和（或）泛耐药，治疗药物选择性不强，导致临床治疗困难，从而导致预后较差。且MRSA对环境因素有很强的适应能力，易在医院内传播流行，造成院内感染，已成为医院感染最多见的病原菌之一[3]。利