硝苯地平与硫酸镁治疗早产的效果比较.docVIP

硝苯地平与硫酸镁治疗早产的效果比较 　　[摘要] 目的 探讨硝苯地平作为宫缩抑制剂防治早产的临床疗效。 方法 选择2011年1月～2012年12月早产临产及先兆早产孕妇122例，随机分为观察组和对照组，观察组60例采用硝苯地平治疗，对照组62例采用硫酸镁治疗，对比两组疗效及药物不良反应。 结果 硝苯地平组及硫酸镁组治疗后显效时间分别为（40.12 ±19.48）min及（43.23±18.76）min ；保胎成功率分别为78.3%（47/60）及74.1%（46/62），两组差异无统计学意义（P0.05）；新生儿分娩时体重、Apgar评分差异无统计学意义（P0.05）。硝苯地平组发生药物不良反应6例，硫酸镁组发生药物不良反应20例，两组差异有统计学意义（P0.05）。 结论 硝苯地平防治早产的疗效与硫酸镁相近，但药物不良反应小，口服给药方便，母胎安全性高，值得临床推广应用。 　　[关键词] 硝苯地平；硫酸镁；早产 　　[中图分类号] R714.21 [文献标识码] A [文章编号] 1674-4721（2013）11（b）-0082-02 　　Efficacy comparison of nifedipine and magnesium sulfate in the treatment of premature labor 　　YANG Lin HUANG Xiao-yun SHAO Jun-hui HU Chun-fang 　　Maternal and Child Health Hospital of Xinyu City in Jiangxi Province， Xinyu 338025， China 　　[Abstract] Objective To explore the clinical effects of nifedipine as tocolysis in the prevention and treatment of premature labor. Methods 122 women with preterm labor or threatened premature labor from January 2011 to December 2012 were randomly divided into observation group and control group. In the observation group （n=60）， patients were provided with nifedipine while in the control group （n=62）， patients were treated by magnesium sulfate. The therapeutic effects and adverse drug reactions （ADR） in both groups were compared. Results Effective time in the observation group and control group after treatment was（40.12±19.48） min and （43.23±18.76） min respectively. The success rates of prevent miscarriage were 78.3%（47/60） and 74.1%（46/62）. The above indexes didn′t display significant differences in both groups （P0.05）. The birth weight and Apgar scoring showed no statistical differences in the two groups （P0.05）. The number of ADR cases in the observation group and control group was 6 and 20 cases in turn， which displayed a statistical difference （P0.05）. Conclusion In the prevention and treatment of premature labor， the effect of nifedipine is similar to magnesium sulfate， but with lower occurrence of ADR， more convenient oral administration， and sa