伐地那非对急性肺血栓栓塞症家兔的治疗效果研究.docVIP

伐地那非对急性肺血栓栓塞症家兔的治疗效果研究 　　[摘要] 目的 探讨伐地那非治疗急性肺血栓栓塞症（APTE）的疗效及可行性。 方法 选用日本大耳纯种家兔36只，随机分为4组，每组9只，分别为空白对照组、APTE模型组、伐地那非低剂量组、伐地那非高剂量组。对家兔进行急性肺血栓栓塞症造模，APTE组无药物干预；伐地那非低剂量组：予伐地那非片1.5 mg/kg治疗；伐地那非高剂量组：予伐地那非片3.0 mg/kg治疗。测定家兔栓塞后各时间点（0 h，1 h，2 h，4 h）的动脉血气、肌钙蛋白（cTnI）、N端前脑钠肽（NT-proBNP）、右室收缩压（RVSP）、平均动脉压（MAP）并比较各组数据。 结果 APTE模型组与伐地那非低、高剂量组检验结果差异均具有统计学意义（P 0.05）；伐地那非低、高剂量组检验结果差异具有统计学意义（P 0.05）。 结论 伐地那非可改善急性肺血栓栓塞家兔的动脉血气、NT-proBNP、cTnI及血流动力学指标，对肺栓塞有一定的治疗效果。 　　[关键词] 急性肺血栓栓塞；5型磷酸二酯酶抑制剂；伐地那非 　　[中图分类号] R563.5 [文献标识码] A [文章编号] 1673-9701（2013）25-0010-04 　　Therapic effect research on vardenafil for acute pulmonary thromboembolism rabbits 　　CHEN Zhili MIAO Xinjun CHEN Yuxi 　　Department of Emergency， Wenzhou Central Hospital in Zhejiang Province， Wenzhou 325000， China 　　[Abstract] Objective To investigate the therapic effect and feasibility of vardenafil in the treatment of acute pulmonary thromboembolism（APTE）. Methods A total of 36 Japan large ear purebred rabbits were randomly divided into 4 groups， respectively for the control group， the APTE model group， the low-dose vardenafil group， the high-dose vardenafil group， and each group had 9 rabbits. The APTE model of rabbits were made. The APTE model group were given non-drug intervention， while the low-dose vardenafil group were given 1.5 mg/kg vardenafil treatment， and the high-dose vardenafil group were given 3.0 mg/kg vardenafil treatment. The arterial blood gas， cardiac troponin I（cTnI）， N-terminal pro B-type natriuretic peptide （NT-proBNP）， right ventricular systolic pressure （RVSP）， mean arterial pressure（MAP） of rabbits at 0 h， 1 h， 2 h and 4 h after transarterial chemoembolization were determined and compared. Results The differences were statistically significant in examination results among the APTE model group， the low-dose vardenafil group and the high-dose vardenafil group （P0.05）. There were significant differences in examination results between the low-dose vardenafil group and the high-dose vardenafil group （P0.05