清肝解毒汤联合更昔洛韦眼用凝胶治疗单纯疱疹病毒性角膜炎的疗效及预防复发作用.docVIP

清肝解毒汤联合更昔洛韦眼用凝胶治疗单纯疱疹病毒性角膜炎的疗效及预防复发作用 　　[摘要] 目的 探讨清肝解毒汤联合更昔洛韦眼用凝胶治疗单纯疱疹病毒性角膜炎（HSK）的疗效及预防复发作用。方法 选择68例HSK患者，随机分为观察组与对照组。两组患者均予以用0.15%更昔洛韦眼用凝胶滴眼，4次/d，每次2滴，观察组加用口服自清肝解毒汤，1剂/d，连用4周。对照组除不口服清肝解毒汤外余治疗同观察组。结果 治疗4周后，观察组的总有效率明显高于对照组（χ2=6.48，P0.05）。对治疗有效者治疗后随访6个月和1年，观察组复发率明显低于对照组（χ2=4.74、6.39，P0.05）。 结论 清肝解毒汤联合更昔洛韦眼用凝胶治疗HSK的疗效确切，能明显提高视力，安全性较好；且能明显降低HSK的复发率，具有治疗和预防HSK复发的作用。 　　[关键词] 单纯疱疹病毒性角膜炎；清肝解毒汤；更昔洛韦眼用凝胶；复发 　　[中图分类号] R772.21 [文献标识码] B [文章编号] 1673-9701（2013）25-0101-03 　　Curative effect and preventive reoccurrence function of liver detoxification soup combined with ganciclovir ophthalmic gel on herpes simplex keratitis 　　HUANG Xiaoyun 　　Department of Ophthalmology， Hanghzou Yuhang Hospital of Traditional Chinese Medicine in Zhejiang Province， Hangzhou 311106， China 　　[Abstract] Objective To discuss the curative effect and reoccurrence prevent function of liver detoxification soup combined with ganciclovir ophthalmic gel on herpes simplex keratitis （HSK）. Methods Sixty-eight cases of HSK patients were divided into observation group and control group randomly. The patients in two groups were given 0.15% ganciclovir ophthalmic gel dripped into the eyes 2 drips for one time and 4 times daily. The patients in observation group were given liver detoxification soup by the mouth. Except for liver detoxification soup， the patients in control group were given the same medical treatment as that in observation group. Results After 4 weeks’ medical treatment， the total clinical efficiency of patients in observation group was much higher than that in control group （χ2=6.48，P0.05）. The follow-up of patients， who had be given effective treatment， was carried on after 6 month and 1 year of the medical treatment， and the reoccurrence rate in observation group was obviously lower than that in control group （χ2=4.74 and 6.39， P 　　[Key words] Herpes simplex keratitis （HSK）； Liver detoxification soup； Ganciclovir ophthalmic gel； Reoccurrence 　　单纯疱疹性病毒性角膜炎（HSK）是一种临床常见的病毒感染性角膜病，主要由单纯性疱疹病