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Kristine Ruggiero CPNP, MSN, RN Chapter 29 Alterations in Cellular Growth Differences between Pediatric and Adult presentation of Cancer Incidence of Cancer in Childhood: Approximately 9,000 children diagnosed in United States in 2003 Cancer is the leading cause of death for children under age 15 In 2003, about 1,500 children died of cancer, 1/3rd from leukemia Types of tumors vary by age and affect survival rate FIGURE 29–1 Percentage of primary tumors by site of origin for different age groups. Notice that in the early years of life, in addition to leukemia, cancers that derive from embryonic cells such as sympathetic nervous system (neuroblastoma) and eye (retinoblastoma) are common. As the child grows, lymphoma becomes more common in school years, and germ cell cancers of ovary and testes emerge as more common causes in teens. Anatomy and Physiology of Pediatric Differences Immune system more immature in children This affects how well body can defend itself Nonspecific and specific cellular responses are immature in infants and premies Children are still growing and developing As a result, some cancers grow and progress more rapidly Apoptosis (programmed-cell death) not well-developed in young children Children more commonly present with metastases at time of dx than adults d/t the difficulty in recognizing s/sx of cancer (usually mistaken for childhood illness) Differences between adults and children with cancer Childhood cancers respond better to chemotherapy Children tolerate chemotherapy better than adults Childhood survivors of cancer need to be monitored for late-effects and long-term side effects of cancer treatment “Late-effects” clinics Etiology and Pathophysiology Alterations in cellular growth occur in response to external and internal stimuli Neoplasms are caused by one or a combination of three factors; External stimuli that cause genetic mutations Innate immune system and gene abnormalities Chromosomal abnormalities FIGURE 29–2 A pro
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