呼吸病理肿瘤__培训课件.pptVIP

* Solid Area Here, note the collections of foamy macrophages (large cells) among the tumor cells. Mitoses were very infrequent. * Foam Cells and Hemosiderin Some of the spaces contained foamy macrophages and hemosiderin-filled macrophages (center) rather than blood. Hemosiderin-filled macrophages are also scattered throughout the surrounding tumor. * Collagenous tissue replaces tumor cells in the sclerotic pattern of growth. Necrosis, calcification, and foreign-body granulomas around cholesterol clefts are occasional features of the tumor. Note the large hemangioma-like spaces. * 1088 These neuroendocrine (argyrophilic) cells are found next to bronchial glands and in the surface epithelium where they appear to have clear cytoplasm, histologically. They are metabolically active, have dense core neurosecretory granules which contain a variety of peptide hormones (serotonin, calcitonin, and bombesin), and have finger-like cytoplasmic extensions which reach the airway lumen. Kulchitsky cells may be related to certain lung neoplasms (i.e. small cell carcinoma and carcinoid tumors) that often secrete hormonally active substances. Although their precise function is as yet poorly understood, they seem to be involved in glandular secretion as well as vascular and bronchial tone. (see Neuroepithelial bodies; carcinoid tumor) 神经内分泌细胞 * 1090 : Normal brionchiole, high power. 正常细支气管 * 1092 :Normal lung parenchyma, low power. The acinus is the functional or terminal respiratory unit of the lung and includes all structures from the respiratory bronchiole to the alveolus (alveolar ducts, alveolar sacs, and alveoli). An acinus averages 0.75 mm in diameter. Each person has about 20,000 acini and 300 million alveoli. The lobule is a less well-defined anatomic unit which includes 3-5 terminal bronchioles and their distal structures. * 378 Epidermoid carcinoma in situ, bronchus, lung, high power.Epidermoid carcinoma in situ, bronchus, lung, high power * 379 Epidermoid carcinoma in