高脂血症对HER2过表达型乳腺癌预后的影响讲稿.docVIP

高脂血症对HER2过表达型乳腺癌预后的影响 熊臣1，罗振宇3，喻译锋2，张尊1，晏露2，张京伟2，魏蕾1* 【摘要】目的：分析高脂血症对HER2过表达型乳腺癌预后的。方法：通过筛选出首次病理确诊为HER2过表达型的乳腺癌患者，比较术前检测血脂正常的患者与高脂血症患者在巩固期治疗后短期内的转移、复发与死亡率的差异。结果：在HER2过表达型乳腺癌患者中，血脂异常组的复发转移率与死亡率均高于血脂正常组，差异有显著性（P＜0.05）。结论：高脂血症可能与HER2过表达型乳腺癌患者的不良预后有密切关系。 【关键词】高脂血症；HER2过表达型乳腺癌；预后 Relationship of Hyperlipidemia with Prognosis of the HER-2 overexpressed Breast Cancer Patients XIONG Chen1, LUO Zhen-yu2, YU Yi-feng 2, ZHANG Zun1, YAN Lu2, ZHANG Jing-wei2, WEI Lei1* 1Department of Pathology and Pathophysiology,School of Medicine, Wuhan University, Wuhan 430071, China. 2Zhongnan Hospital of Wuhan University, the Second College of Clinical Medicine of Wuhan University, Wuhan, Hubei 430071, PR China. 3Renmin Hospital of Wuhan University, the First College of Clinical Medicine of Wuhan University, Wuhan, Hubei 430060, PR China. *Correspondence author 【Abstract】Objective：To explore the relationship of the hyperlipidemia and prognosis of the HER-2 overexpressed breast cancer. Methods: Through a follow-up in HER-2 overexpresssion breast cancer patients during the period of consolidating the therapeutic effect, the recrudescence and metastasis rate and the fatality rate of patients with dyslipidemia were compared with those of patients with high blood lipid. Results：The recrudescence and metastasis rate and the fatality rate in HER-2 overexpressed breast cancer patients with hyperlipidemia were significantly higher than the patients with normal blood lipid (P0.05). Conclusion: The poor prognosis of the HER-2 overexpressed breast cancer may correlate with the dyslipidemia. Key words: Hyperlipidemia；HER-2 overexpressed breast cancer；Prognosis. 在多种上皮来源的恶性肿瘤中，HER2都存在过表达[1]。而HER2（human epithelial growth fator receptor-2）过表达型乳腺癌是乳腺癌分子分型中的一种，其ER、PR的表达均成阴性。如今，乳腺癌是女性最常见的恶性肿瘤之一，侵袭和转移是导致乳腺癌预后差的主要因素。近年来，我国每年因乳腺癌死亡的人数呈逐年增高趋势，乳腺癌已成为严重威胁女性健康的第一杀手。因此积极探索乳腺癌的预防和治疗有着重要的社会和实践价值。 随着人们生活水平的不断提高以及饮食结构的改变，与高血脂症相关的代谢性疾病已经成为一种常见、多发疾病。其中，高脂血症、糖尿病等与乳腺癌发生、发展以及预后之间的关系越来越多地引起人们关注[2]。研究提示，血脂增高不仅