偏头痛患者先兆症状与幽门螺杆菌caga阳性株关系的临床研究.docVIP

偏头痛患者先兆症状与幽门螺杆菌CagA阳性株关系的临床研究 【摘要】nbsp; 目的 探讨幽门螺杆菌（Hp）CagA-阳性菌株感染与偏头痛先兆的关系。方法 采用C13-尿素呼气试验确定Hp感染。两组全部的Hp感染者进行其幽门螺杆菌Ⅰ型CagA-阳性的菌株的测定,观察有先兆的偏头痛患者和无先兆的偏头痛患者HpCagA-阳性的菌株感染情况。同时观察抗Hp三联疗法的疗效。结果 有先兆的偏头痛患者其幽门螺杆菌Ⅰ型CagA-阳性的菌株的检出率（81.33％）显著高于无先兆的偏头痛患者的幽门螺杆菌Ⅰ型CagA-阳性的菌株的检出率（30.67％）（Plt;0.001）；经过4周的抗幽门螺杆菌治疗后，两组患者的幽门螺杆菌Ⅰ型CagA-阳性的菌株的检出率显著低于治疗前［分别为10.67%和6.67%；Plt;0.001和Plt;0.01（与治疗前相比）］。结论 幽门螺杆菌Ⅰ型CagA-阳性的菌株的感染可能是偏头痛患者先兆症状产生的原因。抗Hp治疗能显著改善偏头痛患者的先兆症状。 【关键词】nbsp; 偏头痛 幽门螺杆菌 CagA-阳性菌株 nbsp;nbsp;nbsp; Clinical study on association between Helicobacter pylori cytotoxic type I CagA-positive strains and migraine with aura nbsp;nbsp;nbsp;nbsp;nbsp; ［Abstract］nbsp; Objectivenbsp; To study the association between Hp cytotoxic type I CagA-positive strains and migraine with aura.Methodsnbsp; The migraine patients were divided into two groups according to patients with or without aura.Hp were detected withnbsp; C expiration test in migraine patients.Thenbsp; Hp infected patients werenbsp; further detected for Hp cytotoxic type I CagA-positive strains.The curative effects of three combined anti-Hp infection treatment were observed.Resultsnbsp; The infected rates of Hp cytotoxic type I CagA-positive strains in migraine patients with aura were significantly higher than thatnbsp; innbsp; migraine patientsnbsp; without aura（81.33％nbsp; vs 30.67％;Plt;0.001）.After four weeks’ anti-Hp therapy,the infected rates of Hp cytotoxic type I CagA-positive strains werenbsp; lower in both groups than before.Conclusionnbsp; Hp cytotoxic type I CagA-positive strainsnbsp; infectionnbsp; may probablynbsp; benbsp; annbsp; importantnbsp; factor in pathogenesis ofnbsp; migraine with aura.Anti-Hp therapy may be effective in treatment to migrainenbsp; patients withnbsp; aura. nbsp;nbsp;nbsp; ［Key words］nbsp; migrane;Helicobacter pylori；CagA-positive strains nbsp;nbsp;nbsp; 偏头痛的发病机制至今尚不清楚，既往认为是一种脑血管舒缩功能障碍性疾病。但近几年的研究表明，幽门螺杆菌（H.pylori,Hp）感染在偏头痛的发病机制中亦起着较重要的作用。但是，典型的偏头痛发作具有先兆症状。偏头痛发作与幽门螺杆菌感染有