布地奈德与硫酸特布他林雾化吸入治疗儿童支气管哮喘急性发作疗效观察.docVIP

布地奈德与硫酸特布他林雾化吸入治疗儿童支气管哮喘急性发作疗效观察 　　摘要：目的：观察布地奈德联合硫酸特布他林雾化吸入治疗儿童支气管哮喘急性发作的临床疗效。方法： 将82例支气管哮喘急性发作患儿随机分为2组，对照组40例和治疗组42例，两组采用相同的抗感染、止咳、平喘、吸氧等综合治疗，治疗组给予布地奈德1mg联合硫酸特布他林250ug氧气雾化吸人，入院的第一小时内每20分钟吸入一次，再以Q8h吸入，对照组静脉使用地塞米松，治疗2～3天比较两组临床症状体征消失的时间，对临床疗效和不良反应进行评估。结果 ：治疗组咳嗽、喘息、呼吸困难、肺部哮鸣音消失时间均明显短于对照组；治疗组有效率为92.9%，对照组有效率为77.5%，两组比较差异有统计学意义（P〈0.05））。结论： 布地奈德联合硫酸特布他林雾化吸入治疗儿童支气管哮喘急性发作能迅速缓解临床症状、体征，疗效确切，且具有协同作用，安全性高，值得临床推广使用。 　　关键词：布地奈德；特布他林；雾化吸入；支气管哮喘 　　【Abstract】Object：To observe the therapeutic effect of Budesonide Combined with Terbutaline Sulfate in treatment of Children with Asthma of Acute Attack through atomization inhalation. Methods：In all 82 cases of children with acute bronchial asthma were divided into a treatment group （n=42 ）and a control group （n=40 ）. Two groups of the same resistance to infection， cough， and asthma ， oxygen and other comprehensive treatment. Treatment group was given 1 mg budesonide combined with terbutaline sulfate 250ug oxygen atomization inhalation， every 20 minutes in the first hours of admission to inhale once， again with Q8h suction. The control group vein using dexamethasone. Treatment 2-3 days to compare two groups of clinical symptoms and signs disappeared， to evaluate clinical therapeutic effects and adverse reactions. Results： Treatment group cough，wheezing，difficulty breathing，lung wheezing sound disappear time were significantly shorter than the control group（p〈0.05）. Conclusions： Budesonide combined with Terbutaline Sulfate aerosol inhalation treatment of children with asthma acute episodes can quickly relieve the clinical symptoms， signs， curative effect， and has synergy，high safety，worth clinical promotion use. 　　[Key words] Budesonide； Terbutaline Sulfate； Inhalation； Bronchial asthma 　　【中图分类号】R730.53 【文献标识码】A 【文章编号】1672-8602（2015）03-0266-02 　　支气管哮喘是儿童期最常见的慢性呼吸道疾病，是由多种细胞（如嗜酸性粒细胞、肥大细胞、T淋巴细胞、中性粒细胞及气道上皮细胞等）和细胞组分共同参与的气道慢性炎症性疾病，表现为反复发作性的喘息、气促、胸闷或咳嗽等症状，并伴有气道高反应性的可逆性、梗阻性呼吸道疾病。支气管哮喘可在任何年龄发病，70%～80%儿童哮喘发病于5岁以前，儿童哮喘如诊治不及时，随病程的延长可产生气道不可逆