电针对高脂血症大鼠血脂、超敏C反应蛋白、脂联素的调节作用技术总结.docVIP

电针对高脂血症大鼠血脂、超敏C反应蛋白脂联素血脂、超敏C反应蛋白（HS-CRP）、脂联素（Adiponectin，ADPN）的调节作用及作用机理。Wistar大鼠32只，随机分为正常对照组、模型组、手针组、电针组每组8只。采用高脂饲料饮食造模，正常对照组给予基础饲料，余组均给予高脂饲料，平均每只大鼠30g/日。连续喂养40天，造模成功后，手针组针刺大鼠“后三里”和“中脘”穴。电针组针刺并用电针刺激。4周后抽血观察不同处理因素对血清TC、TG、LDL-C、HDL-C、采用免疫散射比浊法应用酶联免疫法进行检测TC、TG、LDL-C、HS-CRP显著高于对照组(P0.05或P0.01)，HDL-C 、ADPN显著低于对照组（P0.05）。电针组、手针组 TC、TG、LDL-C、HS-CRP显著低于模型组(P0.05或P0.01)，HDL-C、ADPN显著高于模型组（P0.01）。手针组 TC、TG、LDL-C、HS-CRP高于电针组(P0.05或P0.01)，HDL-C、ADPN显著低于电针组（P0.01）。手针组HDL-C和电针组无统计学差异。 结论：电针和手针可以有效的调节高脂血症大鼠的血脂水平，并可以降低HS-CRP水平，升高脂联素（ADPN）的水平。电针疗效优于手针。 关键词：电针；高脂血症；超敏C反应蛋白；脂联素 The effect of Electro-Acupuncture on blood-lipid, high-sensitivity C-reactive protein(HS-CRP) and adiponectin (ADPN) in hyperlipidemia rats Yan zhikang,Yang zhijie,Chen Feng (Department of Acu-moxibustion,Renmin Hospital oh Wuhan University) Abstract： Objective: The purpose of this study was to observe the effect and principle of electro-acupuncture on blood-lipid, high-sensitivity C-reactive protein(HS-CRP) and adiponectin (ADPN) in hyperlipidemia rats. Methods: 32 male Wistar rats were randomly divided into four groups:control group, hyperlipidemia model group, acupuncture group, electro-acupuncture group.With 8 rats in each group. Except for the control group,hyperlipemic rats were induced by high fat diet, the average daily per rat 30g. Feed the rats for 40 days.After 4 weeks of acupuncture and electro- acupuncture,serum levels of triglyceride(TG), total cholesterol(TC), high density lipoprotein cholesterol(HDL-C) ,low density lipoprotein cholesterol (LDL-C), high-sensitivity C-reactive protein (HS-CRP)and adiponectin(ADPN)were detected. Results: After treatment for 4 weeks, the levels of TC,TG,LDL-C, HS-CRP in electro-acupuncture group, acupuncture group were reduced (P0.05 or P0.01) and the levels of HDL-C、were elevated (P0.01), compared with hyperlipidemia model group. Conclusion: Electro-acupuncture has modulation effect on hyperlipidemia and can reduce the level of HS-CRP, increase the level of adi