低温新生儿缺氧缺血性脑病神经保护治疗__培训课件.pptVIP

主要结果 低温治疗伴随不良反应 6项RCT研究结果 study Ratio cooled: controls Cooling method Core temperature achieved (°C) Duration of cooling (hours) Primary outcome Adverse events Follow-up period CoolCap trial (Gluckman et al, 2005) 116:118 selective 34-35 72 Rates of death and severe disability 18 NICHD trial (Shankaran et al, 2005) 102:106 systemic 33.5 72 Rates of death and moderate severe disability↓ 18 TOBY trial (Azzopardi et al, 2009 163:162 systemic 33-34 72 Rates of death and severe disability 18 neo.nEURO.network (Simbruner et al, 2010 64:65 systemic 33-34 72 Rates of death and severe disability↓ N