调激宁冲剂配合激素治疗小儿原发性肾病综合征临床观察.docVIP

调激宁冲剂配合激素治疗小儿原发性肾病综合征临床观察 　　内容提要　目的：研究调激宁冲剂配合激素治疗小儿原发性肾病综合征的作用。方法：选择60例住院患儿，随机分为两组，治疗组30例用调激宁冲剂配合激素，对照组30例单用激素，疗程均为8周。观察治疗前后尿蛋白、血清白蛋白、总胆固醇、血小板及血压的变化。结果：治疗组总有效率、完全效应率明显高于对照组(P＜0.01)，尿蛋白转阴时间明显缩短(P＜0.05)。与对照组比较，在降低血脂、血小板、预防高血压方面亦优于对照组(P＜0.01)。结论：调激宁冲剂能增强激素治疗小儿原发性肾病综合征的疗效，并减轻其副作用，此法安全、有效，值得推广。 Clinical Observation of Tiaojining Recipe in Combination with Corticosterone in Infantile Primary Nephrotic Syndrome 　　Objective: To investigate the effects of Tiaojining recipe (TJNR) combined with corticosterone (CS) in treating infantile primary nephrotic syndrome (IPNS).Methods: Sixty inpatients with IPNS were divided into two groups, which consisted of 30 cases as the treated group treated by TJNR combined with CS and 30 cases of the control group were treated by CS alone for 8 weeks. The changes of urinary protein, serum albumin, blood cholesterol, platelet and blood pressure before and after treatment were observed.Results: The total effective rate of the treated group was significantly higher than that of the control group (P＜0.01). The times for urinary protein disappearance of the treated group was significantly shorter than that ofamp;nbs p;the control group (P＜0.05). Compared with the control group. TINR could prevent hypertension, lower lipidemia and platelets (P＜0.01).Conclusion: TJNR could enhance the curative effects of CS on IPNS and reduce the side-effects of CS safely and effectively. 　　Key words　Tiaojining recipe, corticosterone, infantile primary nephrotic syndrome 　　1990～1996年，我们采用中药调激宁冲剂配合激素治疗小儿原发性肾病综合征，对提高激素疗效并减轻其副作用等方面进行了系统观察。现将其临床资料总结如下。 　　临床资料 　　所有病例均符合1981年第八届儿科大会修订的《关于小儿肾小球疾病临床分类和治疗》中肾病诊断标准(1)，并为初次治疗或复发，反复后需重新足量激素诱导缓解者。所选病例均为同期住院患儿，随机分为两组。治疗组和对照组各30例。其中治疗组男24例，女6例；年龄1.5～13岁，平均5.5岁；初发21例(19例为单纯型，2例为肾炎型)，病程5天～5个月，平均29.1天；复发或反复9例(8例为单纯型，1例为肾炎型)，病程10个月～3年，平均17.7个月。对照组男24例，女6例；年龄1～12岁，平均5.9岁；初发23例(21例为单纯型，2例为肾炎型)，病程5天～4个月，平均26.0天；复发或反复7例(均为单纯型)，病程2.5个月～4年，平均16.9个月。病情程度：尿蛋白定性：治疗组＋＋＋～＋＋＋＋29例，＋＋1