物质依赖个体治疗结束的P3的关系.pptxVIP

Association of P3 amplitude to treatment completion in substance dependent individuals物质依赖者治疗的完成和P3波幅有关系Psychiatry Research(2010)精神病学研究IF: 2.682一、问题提出1、Substance abuse is a serious public health problem, with 19.1 million current substance users in the United States (SAMHSA，2006)。 Although numerous treatments have been used for substance abuse and dependence, retaining clients in treatment is a significant challenge with high dropout rates common。 物质乱用是一个严重的公众健康问题，当前在美国大约有1910万的物质使用者(SAMHSA, 2006) 。尽管存在很多治疗物质乱用和依赖的方法，但是在治疗中面对高脱落率依然是治疗保持率的一个重大挑战 。 {首先点题，说明物质依赖确实是一个重要的社会问题，需要关注}2、 Numerous factors have been identified as predictors of treatment outcome in substance dependence。 Severity of dependence or withdrawal， psychiatric comorbidity，substance-related problems, motivation，length of treatment, cognitive factors， personality traits and disorders， multiple substance abuse， genetic factors，economic and social factors ， depression and alcohol ，impulsivity have all been identified as useful。 研究表明有很多因素可以预测物质依赖者的治疗效果。例如物质依赖和戒断的程度、伴随的精神疾病、物质相关问题、动机、治疗时间长短、认知因素、人格特质和障碍、多种物质的使用、基因、经济社会因素、抑郁情绪、酒精使用、冲动性等都是非常有效的预测因素因素。{说明现在已经有很多的客观因素来预测治疗效果，但是好像还缺少脑点方面的预测治疗}3、As reduced P3 amplitude and prolonged P3 latency have been consistently observed in patients with substance dependence, P3 amplitude is a good candidate for the prediction of treatment completion。 Berman et al. (1993) and Hill et al。 (1995) found that adolescents who show P3 abnormalities before any use of alcohol and drugs are more likely to develop substance abuse in later life。 Low P3 amplitude has been associated with the development of substance abuse and relapse。 P3可以作为预测治疗完成的很好的指标，在物质依赖患者中发现P3波幅减弱，和P3潜伏期的延长。Berman et al. (1993和Hill et al. (1995) 就发现在使用酒精和药物之前，如果的青少年的P3波显示不正常，那么更容易在后面的生活中出现物质乱用。而低P3波幅和出现物质乱用、复发相关。{进一步的表明此研究要关注的是P3，而且P3确实和物质依赖的治疗完成和复发有关，所以，此研究是有效的}二、研究假设 1、 Low P3 amplitude has been associated with the development of substance abuse and relapse。In this study，we were interestedin the usefulness