Entorhinal Cortex Layer III Input to the Hippocampus Is内嗅皮质层III输入到海马.pptVIP

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Entorhinal Cortex Layer III Input to the Hippocampus Is内嗅皮质层III输入到海马.ppt

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Entorhinal Cortex Layer III Input to theHippocampus Is Crucial for TemporalAssociation Memory Junghyup Suh1, Alexander J. Rivest1, Toshiaki Nakashiba1, Takashi Tominaga2, Susumu Tonegawa2 1.The Picower Institute for Learning and Memory, RIKEN–MIT Center for Neural Circuit Genetics, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. 2 Department of Neurophysiology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Kagawa, Japan Science VOL 334 9 December 2011 Background Associating temporally discontinuous elements is crucial for the formation of episodic and working memories that depend on the hippocampal-entorhinal network. The neural circuits subserving temporal association memory have remained unknown. The layer III inputs of the entorhinal cortex to the hippocampus may contribute to this process. 2 EC HP In contrast to the TSP’s demonstrated roles in episodic memory processing, such as pattern completion and separation, the MSP’s contributions remain poorly known. The hypothesis is that the MSP is necessary for temporal association memory. Fig. 1A: the tri-synaptic pathway (TSP) originating from EC layer II and the monosynaptic pathway (MSP) originating from EC layerIII (ECIII) 3 X-gal staining and thionin staining on brain sections from the progeny of pOxr1-Cre and Rosa26 crosses revealed that, by 12 weeks of age, Cre-loxP recombination was restricted to superficial layers of the dorsal portion of the medial EC (MEC) and occurred sparsely in the lateral EC (LEC) 4 Double immuno-fluorescence staining of horizontal sections of pOxr1-Cre/Rosa26 mouse indicated that recombination was mostly confined to excitatory neurons in the MEC superficial layers. anti–β-galactosidase(red) anti-NeuN(green) anti–β-galactosidase (red) anti-parvalbumin (green) 5 Neuronal tracing experiments using the retrograde tracer AlexaFluor488–cholera toxin subunit B (CTB) F: str