22developmentofcardiovascularsystem.pptVIP

muscular interventricular septum interventricular foramen 室间孔 apex endocardial cushions membranous interventricular septum muscular interventricular septum endocardial cushions bulbar ridges 球嵴 (left right) ④ Partition of the bulbus cordis 心球 the truncus arteriosus 动脉干 two large arteries: aorta pulmonary trunk two ridges － in the walls of the bulbus cordis truncus arteriosus －bulbar ridges ( left right ) two ridges grow fuse together － aorticopulmonary septum 主肺动脉隔 aorta pulmonary trunk ascending aorta pulmonary trunk twist around each other aorticopulmonary septum is not coronal or sagittal in orientation but spiral partition of atrioventricular canal atrium ventricle bulbus cordis (5) The congenital malformations ① atrial septal defects 房间隔缺损 normally * * Development of Cardiovascular System 章 为 Dept. of Histology Embryology zhangwi25091@ It derives from mesoderm Establishment of the early blood circulation Development of the heart * Congenital malformation * Establishment of the early blood circulation (3rd week) blood islands extraembryonic embryonic blood stem cells these capillaries differentiate to: arteries, veins capillaries 2. Development of the heart★ formation of endocardial heart tubes change of location of heart tube establishment of heart’s shape partition of the heart the congenital malformations (1) Formation of endocardial heart tubes cardiogenic area *endocardial heart tubes *paired tubes fuse into single *heart tube link up with blood vessels (embryo, connecting stalk, chorion yolk sac) －primitive cardiovascular system (2) Change of location of heart tube *ventral to the foregut 前肠 *caudal to the oropharyngeal membrane (3) Establishment of heart’s shape ① elongation bulbus cordis 心球 ventricle atrium sinus venosus 静脉窦 bulbus cordis － truncus arter