308nm准分子激光联合复方丙酸氯倍他索乳膏治疗掌跖脓疱病疗效观察.docVIP

308nm准分子激光联合复方丙酸氯倍他索乳膏治疗掌跖脓疱病疗效观察 　　[摘要]目的:评价308nm准分子激光联合复方丙酸氯倍他索乳膏治疗掌跖脓疱病的疗效。方法:将62例掌跖脓疱病患者随机分为三组。治疗组：给予308nm准分子激光治疗，照射3次／周，复方丙酸氯倍他索乳膏外用，每日2次；对照1组：单独给予308nm准分子激光治疗；对照2组：给予复方丙酸氯倍他索乳膏治疗。对照组用法同治疗组。分别于治疗前、治疗后每2周评定患者的症状和体征积分及症状积分下降指数(SSRI)。结果：治疗组和对照1组、治疗组和对照2组治疗4周后的症状和体征积分分别比较，差异有统计学意义（t1=2.532，P＜0.05；t2=2.690，P＜0.05）；治疗组和对照1组治疗4周后的有效率分别为95.83%和66.66%，疗效比较差异有统计学意义（χ2=4.375，P＜0.05）；治疗组和对照2组治疗4周后的有效率分别为95.83%和65.00%，疗效比较差异有统计学意义（χ2=5.053，P＜0.05）。治疗组疗效均显著优于对照组。结论：308nm准分子激光联合复方丙酸氯倍他索乳膏治疗掌跖脓疱病具有较好的疗效。 　　[关键词]掌跖脓疱病；308nm准分子激光；复方丙酸氯倍他索乳膏 　　[中图分类号]R730.57[文献标识码]A [文章编号]1008-6455（2014）08-0644-04 　　 　　Efficacy of 308nm excimer laser in combination with compound Clobetasonl Propionate Cream in the treatment of pustulosis palmaris et plantaris 　　DING Yuan, XIANG Fang,PU Xiong-ming 　　(Department of Dermatology and Venereology,Pepoles Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830001,Xinjiang,China) 　　 　　Abstract:Objective To evaluate the efficacy of 308nm excimer laser combined with compound Clobetasonl Propionate Creamin the treatment of palmoplantar pustulosis.Methods62 cases of palmoplantar pustulosis patients weredivided into 3 groups: the treatment group was given 308nm excimer laser irradiation treatment, 3 times a week; compound Clobetasonl Propionate Cream topical, twice a day. The control group were given alone 308nm excimer laser，3 times a week; (control group 1),or given compound Clobetasonl Propionate Cream，twice a day. (control group 2). the patients symptoms and signs score andsymptom score reducing index ( SSRI) were evaluate in each group before and every 2 weeks af ter treatment.ResultsThe treatment group and control group 1,the treatment group and control group 2 had significant differences between the 4 weeks of symptoms and signs scores after treatment (t1=2.532，P＜0.05；t2=2.690，P＜0.05).The treatment group and the control 1 groups after 4 week of treatment of comparative efficiency (95.83% and 66.66%),the difference was statisticallysignific