32例高脂血症性急性胰腺炎的临床特征和治疗分析.docVIP

32例高脂血症性急性胰腺炎的临床特征和治疗分析 　　【摘要】 目的：探讨高脂血症性急性胰腺炎的临床特征、治疗及转归情况。方法：回顾性分析本院收治的32例高脂血症性急性胰腺炎患者的临床资料，随机选择同期住院的非高脂血症性急性胰腺炎30例作为对照组，观察比较两组患者各项观察指标的差异。结果：高脂血症性急性胰腺炎患者在重度胰腺炎发生率、症状、并发症、住院时间等方面与对照组比较，差异均无统计学意义（P0.05）。两组的血清TG比较差异有统计学意义（P0.05）。1例患者因合并严重呼吸衰竭，家属要求放弃治疗，其余31例患者在常规治疗基础上给予降脂治疗，均获得较好预后。结论：高脂血症性急性胰腺炎临床特征与非高脂血症性急性胰腺炎比较，不具有特殊性，除常规的治疗外，及时降低血浆中高浓度的甘油三酯有助于急性胰腺炎的症状缓解，改善预后。 　　【关键词】 高脂血症性急性胰腺炎； 甘油三酯； 临床特征； 治疗 　　【Abstract】 Objective：To investigate the clinical manifestations，treatments and outcomes of the patients with hyperlipidemic acute severe pancreatitis.Method：The clinical data of 32 cases with hyperlipidemic acute severe pancreatitis were retrospectively analyzed and 30 cases with non-hyperlipidemic acute pancreatitis in the same period were selected as the control group.Result：Compared with the control group，there were no significant differences in the incidence of severe pancreatitis，symptoms，complications and hospital stay of hyperlipidemic patients with acute pancreatitis（P0.05）.There was statistically significant difference in serum TG between two groups（P0.05）.1 case of hyperlipidemic severe acute pancreatitis refused further treatment because of severe respiratory failure.Together with the conventional therapy，the other 31 cases had good prognosis after lipid-lowering therapy.Conclusion：There is no specific clinical symptoms of hyperlipidemic acute severe pancreatitis.In addition to conventional therapy，promptly removal of high concentrations of plasma triglyceride is good for alleviating the symptoms of acute pancreatitis and providing a better prognosis. 　　【Key words】 Hyperlipidemic acute severe pancreatitis； Triglycerid； Clinical manifestation； Treatment 　　First-author’s address：Zhumadian Central Hospital，Zhumadian 463000，China 　　doi：10.3969/j.issn.1674-4985.2014.25.041 　　急性胰腺炎（Acute pancreatitis，AP）是多种原因引起的胰酶在胰腺内激活使胰腺组织自身消化，发生水肿、出血、坏死等的化学炎症反应。高脂血症性急性胰腺炎（hyper acute lipidemic pancreastitis，HLAP）又称高甘油三酯血症性急性胰腺炎，是指由高脂血症引起的胰腺炎。目前在我国，胆源性因素仍为急性胰腺炎的首要发病原因，但随着