兰索拉唑治疗胃食管反流的效果分析.docVIP

兰索拉唑治疗胃食管反流的效果分析 　　[摘要] 目的 探讨兰索拉唑治疗胃食管反流的效果。 方法 选取本院收治的150例胃食管反流患者，随机分为3组，A组给予兰索拉唑15 mg/d，B组给予兰索拉唑30 mg/d，对照组给予安慰剂，比较3组的疗效。 结果 3组患者服药前评分值分别为A组（16.1±4.6）分，B组（15.8±4.5）分，对照组（15.9±4.7）分，服药后1周3组患者评分值分别为A组（10.8±5.2）分，B组（10.0±5.4）分，对照组（12.3±5.5）分，经治疗后B组显效率（52.00%）高于A组（42.00%），明显高于对照组（26.00%），B组的有效率（42.00%）高于A组（40.00%），明显高于对照组（36.00%），差异有统计学意义（P0.05）。 结论 兰索拉唑30 mg/d治疗胃食管反流的效果显著，值得临床推广应用。 　　[关键词] 兰索拉唑；食管反流；效果分析 　　[中图分类号] R573[文献标识码] A[文章编号] 1674-4721（2014）06（b）-0085-03 　　 　　Efficacy of lansoprazole in treatment gastroesophageal reflux (GER) 　　HUANG Li-fei 　　Department of Pharmacy,the Second People′s Hospital of Futian District in Shenzhen City,Shenzhen 518100,China 　　[Abstract] Objective To discuss the efficacy of lansoprazole in the treatment of gastroesophageal reflux (GER). Methods 150 patients with GER treated in our hospital were selected,they were randomly divided into three groups,group A was treated by 15 mg/d lansoprazole,group B was treated by 30 mg/d lansoprazole,and the control group was given placebo,the efficacy of 3 groups were compared. Results Before treatment,the score of group A,B,control group were (16.1±4.6),(15.8±4.5),(15.9±4.7) respectively,after 1 week of treatment,the score of 3 groups turned into (10.8±5.2),(10.0±5.4),(12.3±5.5) respectively,the significant efficiency of group B (52.00%) was significantly higher than group A (42.00%) and control group (26.00%),and the effective rate of group B (42.00%) was significantly higher than group A (40.00%) and control group (36.00%),the differences of 3 groups were statistically significant (P0.05). Conclusion The efficacy of 30 mg/d of lansoprazole in the treatment of GER is obvious,it′s worthy of being promoted and applied in clinic. 　　[Key words] Lansoprazole;Gastroesophageal reflux;Diagnosis 　　胃肠食管反流常常是由于食管腔中胃液过多而接触频繁或者由于食管黏膜因各种原因造成破损而引起的一种疾病[1]。如今人们的生活水平不断提高，暴饮暴食现象时有发生，在我国胃肠食管反流的患病率也逐渐增高，此病的典型症状为反胃、烧灼感等，严重影响人们的生活质量，得到了社会人士的广泛关注。质子泵抑制剂通过作用于胃黏膜进而阻断胃液的分泌，使病情迅速好转，临床效果明显[2-3]。本研究特选取150例经确诊为胃肠