The Diabetes Prevention Program A Randomized 糖尿病预防方案的随机性.pptVIP

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The Diabetes Prevention Program A Randomized 糖尿病预防方案的随机性.ppt

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The Diabetes Prevention Program A Randomized 糖尿病预防方案的随机性

The Diabetes Prevention ProgramOutcomes Study:Long-term Follow-up to A Randomized Clinical Trial to Prevent Type 2 Diabetes in Persons at High Risk The DPP/DPPOS Research GroupNNHRRB Conference November 2011 Sponsors National Institute of Diabetes Digestive Kidney Diseases Other NIH Institutes, Offices National Center on Minority Health and Health Disparities National Institute of Child Health and Human Development National Institute on Aging National Center for Research Resources, GCRC Program Office of Research on Women’s Health National Eye Institute National Heart Lung and Blood Institute Indian Health Service Centers for Disease Control and Prevention Diabetes Prevention Program Outcomes Study Clinics . . . . . . . . . . . . . . . . . . . . . . . . . . Study Timeline 1996-2002: To prevent or delay the development of type 2 diabetes in persons with impaired glucose tolerance (IGT) DPPOS Primary Goal 2002-2013: Prevention of diabetes complications such as kidney, eye and nerve problems, and heart disease DPP Primary Goal Who Joined DPP? Screen (158,177 people) Randomize (3,819 people) Standard lifestyle teaching Intensive Lifestyle (1079 people) Metformin (1073 people) Placebo (1082 people) Troglitazone 585 people Until 6/98 Who Joined DPPOS? 3251 of the original 3819 DPP participants joined DPPOS. 88% of the original DPP participants. Who Joined DPPOS at Shiprock ? 74 DPP participants joined DPPOS. 93% of the original Shiprock DPP participants. Shiprock participants are great! DPP Treatments Lifestyle Goals 7% weight loss 150 minutes activity each week Metformin Goals -850 mg twice daily DPPOS Treatments Original Placebo group HELP classes four times a year Original Metformin group Metformin 850 mg twice daily HELP classes four times a year Original Lifestyle group HELP classes four times a year Boost lifestyle classes twice a year How Many Calories and Fat grams in a Navajo Taco? Fat and Calories i